Antibacterial activity and mechanism of luteolin isolated from Lophatherum gracile Brongn. against multidrug-resistant Escherichia coli
文献类型： 外文期刊
作者： Ding, Yahao 1 ; Wen, Guilan 1 ; Wei, Xingke 2 ; Zhou, Hao 3 ; Li, Chunjie 4 ; Luo, Zhengqin 2 ; Ou, Deyuan 1 ; Yang, Jian 1 ; Song, Xuqin 1 ;
作者机构： 1.Guizhou Univ, Key Lab Anim Genet Breeding & Reprod Plateau Mount, Minist Educ, Guiyang, Peoples R China
2.Guizhou Univ, Coll Anim Sci, Guiyang, Peoples R China
3.Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, Guangzhou, Peoples R China
4.Sichuan Univ, Frontiers Sci Ctr Dis Related Mol Network, Lab Pulm Immunol & Inflammat, Chengdu, Peoples R China
关键词： Lophatherum gracile Brongn.; luteolin; multidrug-resistant Escherichia coli; antibacterial mechanism; untargeted metabolomics
期刊名称：FRONTIERS IN PHARMACOLOGY （ 影响因子：4.4； 五年影响因子：5.0 ）
ISSN：
年卷期： 2024 年 15 卷
页码：
收录情况： SCI
摘要： Infections caused by multidrug-resistant (MDR) bacteria have become a major challenge for global healthcare systems. The search for antibacterial compounds from plants has received increasing attention in the fight against MDR bacteria. As a medicinal and edible plant, Lophatherum gracile Brongn. (L. gracile) has favorable antibacterial effect. However, the main antibacterial active compound and its antimicrobial mechanism are not clear. Here, our study first identified the key active compound from L. gracile as luteolin. Meanwhile, the antibacterial effect of luteolin was detected by using the broth microdilution method and time-kill curve analysis. Luteolin can also cause morphological structure degeneration and content leakage, cell wall/membrane damage, ATP synthesis reduction, and downregulation of mRNA expression levels of sulfonamide and quinolones resistance genes in multidrug-resistant Escherichia coli (MDR E. coli). Furthermore, untargeted UPLC/Q-TOF-MS-based metabolomics analysis of the bacterial metabolites revealed that luteolin significantly changed riboflavin energy metabolism, bacterial chemotaxis cell process and glycerophospholipid metabolism of MDR E. coli. This study suggests that luteolin could be a potential new food additive or preservative for controlling MDR E. coli infection and spread.
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