Residue Behavior and Risk Assessment of Diazepam and Its Metabolites in Crucian Carp (Carassius auratus) After Oral Administration
文献类型： 外文期刊
作者： Shan, Qi 1 ; Huang, Xiaosheng 4 ; Ye, Shucai 4 ; Zhou, Hao 1 ; Xu, Feng 5 ; Li, Jianqiang 4 ; Lin, Jiawei 1 ; Li, Lichun 1 ; Yin, Yi 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Minist Agr & Rural Affairs, Key Lab Prevent & Control Aquat Invas Alien Specie, Guangzhou, Peoples R China
2.Chinese Acad Fishery Sci, Guangdong Prov Key Lab Aquat Anim Immunol & Sustai, Guangzhou, Peoples R China
3.Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, Guangzhou, Peoples R China
4.Zhongshan Agr Sci & Technol Extens Ctr, Zhongshan, Peoples R China
5.Chongqing Fisheries Tech Extens Ctr, Chongqing, Peoples R China
关键词： crucian carp; diazepam; residue behavior; risk assessment; tissue distribution
期刊名称：JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS （ 影响因子：1.7； 五年影响因子：1.7 ）
ISSN： 0140-7783
年卷期： 2025 年 48 卷 3 期
页码：
收录情况： SCI
摘要： Diazepam (DZP), a benzodiazepine medication, is extensively utilized in both human and veterinary medicine and has been frequently detected in fish populations. The use of DZP-laced bait is identified as a predominant contributor to drug residue contamination in fish. Nonetheless, our understanding of the residue profile of DZP in fish and its potential implications for human health remains constrained. This study investigated the residue behavior and dietary intake risks of DZP and its primary metabolites in crucian carp (Carassius auratus) following oral administration. A rapid and sensitive UHPLC-MS/MS method was developed and validated for the reliable quantification of DZP and its identified metabolites. The findings revealed rapid absorption and extensive distribution of DZP in crucian carp, with peak concentrations in plasma and tissues occurring at 1 h. The distribution pattern of DZP, based on calculated AUC, was kidney > liver > plasma > gill > muscle plus skin. The distribution of DZP in plasma and tested tissues followed the decreasing order of kidney > liver > plasma > gill > muscle plus skin according to the calculated AUC. DZP elimination was notably slow, particularly in muscle plus skin, with an elimination half-life of 619.31 h, necessitating at least 70 days for concentrations to fall below the limit of quantitation, suggesting a high likelihood of residue formation in fish from oral DZP administration. DZP was metabolized into nordiazepam and temazepam in crucian carp; nordiazepam is the main metabolite of DZP, which is gradually higher than the parent drug in the elimination phase. The dietary risk assessment suggested that a possible health risk (HQ >= 0.1) was found within 1 day via ingestion of crucian carp after an oral dose of DZP, suggesting that frequent consumption of high-residue crucian carp may cause harm to human health.
- 相关文献
作者其他论文 更多>>
-
Structure dependence of the enhanced sulfur tolerance of core-shell CoMn oxides for benzene oxidation: Discrepant sulfur species and less affected reactant activation
作者：Liu, Yang;Cheng, Lin;Zhang, Di;Zhan, Jingjing;Shan, Jiajia;Zhou, Hao;Yi, Xianliang;Li, Zhonghong;Shen, Xudong
关键词：VOCs; Catalytic oxidation; Manganese oxide; Cobalt decoration; Sulfur resistance
-
Copy Number Variations in Short Tandem Repeats Modulate Growth Traits in Penaeid Shrimp Through Neighboring Gene Regulation
作者：Zhou, Hao;Qiang, Guangfeng;Xia, Yan;Tan, Jian;Fu, Qiang;Luo, Kun;Meng, Xianhong;Chen, Baolong;Chen, Meijia;Sui, Juan;Dai, Ping;Li, Xupeng;Liu, Mianyu;Kong, Jie;Luan, Sheng;Zhou, Hao;Qiang, Guangfeng;Xia, Yan;Tan, Jian;Fu, Qiang;Luo, Kun;Meng, Xianhong;Chen, Baolong;Chen, Meijia;Sui, Juan;Dai, Ping;Li, Xupeng;Liu, Mianyu;Kong, Jie;Luan, Sheng;Xing, Qun
关键词：short tandem repeats; STR; growth trait; penaeid shrimp; molecular breeding
-
Shell color and growth traits share the same major locus in Cyclina sinensis
作者：Li, Hengde;Zhang, Yaqun;Xu, Feng;Li, Donghao;Ma, Xiaodong;Huang, Jingxian;Sun, Xiangshan
关键词：Cyclina sinensis; Shell color; Growth traits; Genome-wide association study
-
Rapid determination of fipronil and its metabolites in aquatic products by modified QuEChERS method coupled with UPLC-MS/MS
作者：Ma, Lisha;Zhou, Hao;Lin, Jiawei;Yin, Yi;Shan, Qi;Li, Lichun;Wei, Ningting;Dai, Xiaoxin;Zhao, Cheng;Liu, Shugui
关键词：Fipronil; aquatic products; UPLC-MS/MS; QuEChERS; risk assessment; analysis methods
-
Alpha-MnO2 catalyst with high formaldehyde oxidation and moisture resistance by joint cerium modification and phosphoric acid post-treatment
作者：Chen, Tian-Yun;Liu, Yang;Zhan, Jingjing;Zhou, Hao;Yi, Xianliang;Li, Zhonghong;Shen, Xudong
关键词：Indoor air; Formaldehyde; Catalytic oxidation; Moisture resistance; Manganese oxide
-
Differential Methylation Analysis of Hypermelanosis in Chinese Tongue Sole (Cynoglossus semilaevis)
作者：Zhang, Yaqun;Xu, Feng;Li, Hengde;Zhang, Yaqun;Zhang, Yitong;Li, Hengde;Xu, Feng;Chen, Songlin
关键词：Reduced representation bisulfite sequencing (RRBS); Tongue sole; Hypermelanosis; DNA methylation
-
Determination of diazepam and its active metabolites in aquatic products and aquaculture environments using modified QuEChERS-based UPLC-MS/MS
作者：Zhou, Hao;Wei, Linting;Lin, Jiawei;Zhao, Cheng;Shan, Qi;Wang, Qing;Yin, Yi;Xu, Feng;Mei, Huiqing;Mu, Yingchun
关键词：
