Differential Methylation Analysis of Hypermelanosis in Chinese Tongue Sole (Cynoglossus semilaevis)
文献类型： 外文期刊
作者： Zhang, Yaqun 1 ; Xu, Feng 1 ; Zhang, Yitong 2 ; Chen, Songlin 4 ; Li, Hengde 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Key Lab Aquat Genom, Minist Agr & Rural Affairs, Beijing, Peoples R China
2.Chinese Acad Fishery Sci, Beidaihe Cent Expt Stn, Qinhuangdao 066100, Peoples R China
3.Shanghai Ocean Univ, Natl Demonstrat Ctr Expt Fisheries Sci Educ, Shanghai, Peoples R China
4.Chinese Acad Fishery Sci, Yellow Sea Fishery Res Inst, Qingdao, Peoples R China
关键词： Reduced representation bisulfite sequencing (RRBS); Tongue sole; Hypermelanosis; DNA methylation
期刊名称：MARINE BIOTECHNOLOGY （ 影响因子：2.8； 五年影响因子：3.0 ）
ISSN： 1436-2228
年卷期： 2025 年 27 卷 3 期
页码：
收录情况： SCI
摘要： Hypermelanosis on the blind side is a major concern in tongue sole (Cynoglossus semilaevis) aquaculture in China and causes great economic loss for farmers. To investigate the relationship between DNA methylation and hypermelanosis, different skin tissues on both the ocular and blind sides of both normal and hypermelanotic fish were used in this study, and set analysis was utilized to narrow and filter the possible, potential, and direct differentially methylated regions (DMRs). A total of 2278, 1015, and 6740 DMRs were discovered, which belonged to 1786, 908, and 4210 genes, for possible, potential, and direct methylation types, respectively. Enrichment analysis revealed that the genes harboring DMRs associated with hypermelanosis were involved in the development of the skeletal system and embryonic organs during morphogenesis. Tens of key genes were mutually found by comparing methylation results with reported transcriptomic, ncRNA, and genetic studies. These results implied that hypermelanosis on the blind side in tongue sole is a complex trait that is affected by both genetic factors and environmental conditions and is regulated by a complicated gene network.
- 相关文献
作者其他论文 更多>>
-
Bile acids help maintain immune homeostasis and enhance antioxidant capacity upon Vibrio infection in leopard coral grouper
作者：Zhang, Junwei;Yang, Bowen;Shi, Meng;Chen, Songlin;Zhou, Qian;Zhang, Junwei;Zhang, Jiquan;Wang, Shengpeng
关键词：Plectropomus leopardus; BAs; Vibrio harveyi infection; Transcriptomics; Metabolomics
-
A QTL associated with vibriosis resistance highlights the significant role of jam2a gene in tongue sole (Cynoglossus semilaevis)
作者：Li, Yangzhen;Chi, Yong;Yan, Xu;Hu, Yuanri;Chen, Songlin;Li, Yangzhen;Chen, Songlin;Li, Zhongming;Jia, Lei
关键词：Genome-wide association; Quantitative trait locus; Transcriptome analysis; Heritability; Immune response
-
Orchestrated immune responses to Mycobacterium marinum natural infection in tongue sole ( Cynoglossus semilaevis)
作者：Li, Yangzhen;Yan, Xu;Chi, Yong;Hu, Yuanri;Wang, Jialin;Chen, Songlin;Li, Yangzhen;Chen, Songlin;Song, Limin;Robeldo, Diego;Mukiibi, Robert;Robeldo, Diego;Mukiibi, Robert;Robeldo, Diego;Mukiibi, Robert
关键词：Mycobacteriosis; Bacterial infection; RNA-Seq; Transcriptome analysis; Disease resistance
-
Genome-wide association study and transcriptome analysis provide the SNPs and molecular insights into the visceral nodular disease tolerance in half-smooth tongue sole (Cynoglossus semilaevis)
作者：Chang, Mengyang;Shi, Kunpeng;Xia, Jinqi;Zhang, Ruixue;Li, Yishuai;Zang, Shaoqing;Tan, Suxu;Wang, Wenwen;Sha, Zhenxia;Chen, Songlin;Sha, Zhenxia;Chen, Songlin
关键词：Cynoglossus semilaevis; Visceral nodular disease; GWAS; RNA-seq; Disease tolerance; Multi omics
-
A newly developed 20 K SNP array reveals QTLs for disease resistance to Cryptocaryon irritans in tiger pufferfish (Takifugu rubripes)
作者：Li, Yangzhen;Fraslin, Clemence;Chi, Yong;Hu, Yuanri;Wang, Jialin;Chen, Songlin;Li, Yangzhen;Mukiibi, Robert;Robledo, Diego;Li, Yangzhen;Li, Weidong;Li, Weiguo;Hu, Yuanri;Wang, Jialin;Chen, Songlin;Houston, Ross D.;Robledo, Diego
关键词：SNP array; Heritability; Genomic prediction; GWAS; QTL; Selective breeding
-
SHP-1 interacts with NFκB1 to inhibit its phosphorylation and nuclear translocation to exert its anti-bacterial function
作者：Wang, Ningning;Tan, Suxu;Wang, Muyuan;Liu, Hongning;Han, Sen;Wu, Zhendong;Ma, Jie;Chen, Songlin;Sha, Zhenxia;Wang, Ningning;Chen, Songlin;Chen, Songlin;Sha, Zhenxia
关键词：SHP-1; Immune response; Phosphorylation of NF kappa B1; Nuclear translocation
-
Identification candidate genes and loci associated with hypermelanosis of the blind side in Japanese flounder ( Paralichthys olivaceus) ) using the combination of RNA-Seq and BSA-Seq
作者：Liu, Mingyang;San, Lize;Zhang, Xiaoyan;Li, Bingbu;Yang, Yucong;Zheng, Xinyu;Zhang, Yitong;He, Zhongwei;Liu, Yufeng;Cao, Wei;Ren, Yuqin;Wang, Yufen;Wang, Guixing;Hou, Jilun;Liu, Mingyang;San, Lize;Zhang, Xiaoyan;Li, Bingbu;Yang, Yucong;Zheng, Xinyu;Zhang, Yitong;He, Zhongwei;Liu, Yufeng;Cao, Wei;Ren, Yuqin;Wang, Yufen;Wang, Guixing;Hou, Jilun;Liu, Mingyang;San, Lize;Zhang, Xiaoyan;Li, Bingbu;Yang, Yucong;Zheng, Xinyu;Zhang, Yitong;He, Zhongwei;Liu, Yufeng;Cao, Wei;Ren, Yuqin;Wang, Yufen;Wang, Guixing;Hou, Jilun;Zhang, Jian;Fang, Xiao
关键词：Recombinant doubled haploid; Paralichthys olivaceus; BSA-seq; Hypermelanosis; Transcriptomic analysis
