Orchestrated immune responses to Mycobacterium marinum natural infection in tongue sole ( Cynoglossus semilaevis)
文献类型： 外文期刊
作者： Li, Yangzhen 1 ; Song, Limin 3 ; Yan, Xu 1 ; Chi, Yong 1 ; Hu, Yuanri 1 ; Wang, Jialin 1 ; Robeldo, Diego 4 ; Mukiibi, Robert 4 ; Chen, Songlin 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, State Key Lab Mariculture Biobreeding & Sustainabl, Qingdao 266071, Peoples R China
2.Qingdao Marine Sci & Technol Ctr, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Shandong, Peoples R China
3.Tianjin Fisheries Res Inst, Tianjin 300221, Peoples R China
4.Univ Edinburgh, Roslin Inst, Edinburgh EH25 9RG, Midlothian, Scotland
5.Univ Edinburgh, Royal Dick Sch Vet Studies, Edinburgh EH25 9RG, Midlothian, Scotland
6.Univ Santiago de Compostela, Dept Genet, Santiago De Compostela 15706, Spain
7.Harper Adams Univ, Dept Anim Hlth Behav & Welf, Newport TF10 8NB, Shrops, England
关键词： Mycobacteriosis; Bacterial infection; RNA-Seq; Transcriptome analysis; Disease resistance
期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：3.9； 五年影响因子：4.2 ）
ISSN： 1050-4648
年卷期： 2025 年 158 卷
页码：
收录情况： SCI
摘要： Mycobacterium marinum is a major pathogen in aquaculture, posing a substantial threat to the health and sustainability of tongue sole ( Cynoglossus semilaevis) farming. This study investigated the genetic basis of immune response in tongue sole by comparing transcriptome profiles of liver and spleen tissues from symptomatic (susceptible) and healthy (resistant) individuals during a natural M. marinum outbreak. Transcriptomic analyses identified differentially expressed genes and enriched pathways related to immune responses. Key genes, including atp6ap1, gpi, and idh3a, were found to be crucial in immune response to M. marinum infection, involved in immune processes such as signal transduction, antigen processing, and metabolic pathways. Protein- protein interaction networks highlighted central hub genes such as nedd8, jun and junb, which play pivotal roles in immune regulation. These findings provide insights into the orchestrated immune responses to mycobacteriosis, which can inform selective breeding strategies for disease-resistant tongue sole strains. This is the first comprehensive transcriptome analysis of M. marinum natural infection in tongue sole, offering valuable data for future research and disease management in aquaculture.
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