A newly developed 20 K SNP array reveals QTLs for disease resistance to Cryptocaryon irritans in tiger pufferfish (Takifugu rubripes)
文献类型： 外文期刊
作者： Li, Yangzhen 1 ; Fraslin, Clemence 1 ; Chi, Yong 1 ; Mukiibi, Robert 2 ; Hu, Yuanri 1 ; Wang, Jialin 1 ; Li, Weiguo 4 ; Li, Weidong 3 ; Houston, Ross D. 6 ; Robledo, Diego 2 ; Chen, Songlin 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, State Key Lab Mariculture Biobreeding & Sustainabl, Qingdao 266071, Peoples R China
2.Univ Edinburgh, Roslin Inst, Midlothian EH25 9RG, England
3.Tangshan Haidu Seafood Co Ltd, Tangshan 063506, Peoples R China
4.Huazhi Biotech Co Ltd, Changsha 410125, Peoples R China
5.Shanghai Ocean Univ, Natl Demonstrat Ctr Expt Fisheries Sci Educ, Shanghai 201306, Peoples R China
6.Benchmark Genet, Penicuik EH26 0GB, England
7.Univ Santiago de Compostela, Dept Genet, Santiago De Compostela 15706, Spain
关键词： SNP array; Heritability; Genomic prediction; GWAS; QTL; Selective breeding
期刊名称：AQUACULTURE （ 影响因子：3.9； 五年影响因子：4.4 ）
ISSN： 0044-8486
年卷期： 2025 年 595 卷
页码：
收录情况： SCI
摘要： This study describes the development and application of a 20 K single nucleotide polymorphism (SNP) array in fugu (Takifugu rubripes). The main goal of this newly developed SNP array is to enhance selective breeding practice via the incorporation of genomic information. Fugu is one of the economic aquaculture species and mainly threatened by parasite disease. The performance of the array was evaluated in a farmed pufferfish population challenged with Cryptocaryon irritans and benchmarked against whole-genome sequencing of a subset of the animals. The array showed very high call rates, consistency between technical replicates, and concordance with genome-resequencing data. Heritability estimates using pedigree and SNP datasets demonstrated a significant genetic component of resistance to C. irritans, with heritability estimates ranging from 0.53 to 0.67, and prediction accuracies were significantly improved with the use of genomic data. Genome-wide association study identified two putative quantitative trait loci (QTLs) on chromosomes 3 and 17. Our findings suggest resistance to C. irritans can be rapidly increased in fugu populations by selective breeding, further expedited via the application of genetic markers. Therefore, they represent a valuable resource for selective breeding programmes aimed at enhancing disease resistance in fugu aquaculture.
- 相关文献
作者其他论文 更多>>
-
Bile acids help maintain immune homeostasis and enhance antioxidant capacity upon Vibrio infection in leopard coral grouper
作者：Zhang, Junwei;Yang, Bowen;Shi, Meng;Chen, Songlin;Zhou, Qian;Zhang, Junwei;Zhang, Jiquan;Wang, Shengpeng
关键词：Plectropomus leopardus; BAs; Vibrio harveyi infection; Transcriptomics; Metabolomics
-
A QTL associated with vibriosis resistance highlights the significant role of jam2a gene in tongue sole (Cynoglossus semilaevis)
作者：Li, Yangzhen;Chi, Yong;Yan, Xu;Hu, Yuanri;Chen, Songlin;Li, Yangzhen;Chen, Songlin;Li, Zhongming;Jia, Lei
关键词：Genome-wide association; Quantitative trait locus; Transcriptome analysis; Heritability; Immune response
-
Orchestrated immune responses to Mycobacterium marinum natural infection in tongue sole ( Cynoglossus semilaevis)
作者：Li, Yangzhen;Yan, Xu;Chi, Yong;Hu, Yuanri;Wang, Jialin;Chen, Songlin;Li, Yangzhen;Chen, Songlin;Song, Limin;Robeldo, Diego;Mukiibi, Robert;Robeldo, Diego;Mukiibi, Robert;Robeldo, Diego;Mukiibi, Robert
关键词：Mycobacteriosis; Bacterial infection; RNA-Seq; Transcriptome analysis; Disease resistance
-
Genome-wide association study and transcriptome analysis provide the SNPs and molecular insights into the visceral nodular disease tolerance in half-smooth tongue sole (Cynoglossus semilaevis)
作者：Chang, Mengyang;Shi, Kunpeng;Xia, Jinqi;Zhang, Ruixue;Li, Yishuai;Zang, Shaoqing;Tan, Suxu;Wang, Wenwen;Sha, Zhenxia;Chen, Songlin;Sha, Zhenxia;Chen, Songlin
关键词：Cynoglossus semilaevis; Visceral nodular disease; GWAS; RNA-seq; Disease tolerance; Multi omics
-
SHP-1 interacts with NFκB1 to inhibit its phosphorylation and nuclear translocation to exert its anti-bacterial function
作者：Wang, Ningning;Tan, Suxu;Wang, Muyuan;Liu, Hongning;Han, Sen;Wu, Zhendong;Ma, Jie;Chen, Songlin;Sha, Zhenxia;Wang, Ningning;Chen, Songlin;Chen, Songlin;Sha, Zhenxia
关键词：SHP-1; Immune response; Phosphorylation of NF kappa B1; Nuclear translocation
-
First genome-wide association and genomic prediction of ammonia-nitrogen tolerance in tiger pufferfish (Takifugu rubripes)
作者：Chi, Yong;Hu, Yuanri;Chen, Songlin;Li, Yangzhen;Chi, Yong;Chen, Songlin;Li, Yangzhen;Chi, Yong;Li, Weidong;Li, Yangzhen;Mukiibi, Robert;Robledo, Diego;Robledo, Diego
关键词：Fugu; Heritability; Environmental stress; GWAS; QTL; Aquaculture
-
Role of the cell cycle-related gene cdk2 and its associated ceRNA network in sexual size dimorphism of Cynoglossus semilaevis
作者：Li, Xihong;Wang, Jiacheng;Mai, Jiaqi;Sun, Yuqi;Li, Wenjie;Cai, Zhenyu;Xu, Wenteng;Chen, Zhangfan;Chen, Songlin;Wang, Na;Li, Xihong;Xu, Wenteng;Chen, Zhangfan;Chen, Songlin;Wang, Na;Wang, Jiacheng;Li, Wenjie;Wang, Na
关键词：Cynoglossus semilaevis; Sexual size dimorphism; cdk2; ceRNA
