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Production of 8-Prenylnaringenin from Isoxanthohumol through Biotransformation by Fungi Cells

文献类型： 外文期刊

作者： Fu, Ming-liang 1 ; Wang, Wei 1 ; Chen, Feng 3 ; Dong, Ya-chen 1 ; Liu, Xiao-jie 1 ; Ni, Hui 1 ; Chen, Qi-he 1 ;

作者机构： 1.Zhejiang Univ, Dept Food Sci & Nutr, Hangzhou 310058, Zhejiang, Peoples R China

2.Zhejiang Acad Agr Sci, Inst Qual & Standard Agr Prod, Hangzhou 310021, Zhejiang, Peoples R China

3.Clemson Univ, Clemson, SC 29634 USA

4.Jimei Univ, Sch Bioengn, Xiamen 361021, Peoples R China

关键词： 8-Prenylnaringenin;isoxanthohumol;biotransformation;identification

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.279； 五年影响因子：5.269 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： 8-Prenylnaringenin (8PN), which presents in hop, enjoys fame as the most potential phytoestrogen. Although a number of health effects are attributed to 8PN, few reports are available about the production of it. In this work, screening of fungi to efficiently transform isoxanthohumol (IXN) into 8PN was designed. The biotransformation of IXN was significantly observed in Eupenkilliwn javanicum, Cunninghamelh blakesleana, and Ceriporiopsis subvermispora under five kinds of transformation conditions. As a comparative result of IXN transformation, B. javanicum was the optimal biocatalyst to produce 8PN. Transformation caused by growing precultured fungal mycelia, a process designated as G2, was a favorable condition for IXN transformation in view of the yield of 8PN. The possible transformation pathway of 8PN bioproduction is postulated in this work. The construction of fungus and transformation mode derived from the current work is viable and an alternative procedure for 8PN formation.

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