Evolutionary and functional insights into Fibrinogen-related protein (FREP) dynamics in sea cucumbers
文献类型： 外文期刊
作者： Li, Shuo 1 ; Li, Chen 2 ; Han, Shenglei 2 ; Chen, Kaiyu 1 ; Li, Weijing 2 ; Jiang, Shuhong 2 ; Liao, Duan 2 ; Shao, Changwei 2 ; Li, Chenghua 1 ;
作者机构： 1.Ningbo Univ, State Key Lab Managing Biot & Chem Threats Qual &, Ningbo 315211, Peoples R China
2.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, State Key Lab Mariculture Biobreeding & Sustainabl, Qingdao 266071, Shandong, Peoples R China
3.Qingdao Marine Sci & Technol Ctr, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Shandong, Peoples R China
关键词： Fibrinogen-related proteins; Sea cucumber; Gene duplication and diversification; Immune adaptation; Chromosomal rearrangements
期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：3.9； 五年影响因子：4.2 ）
ISSN： 1050-4648
年卷期： 2025 年 160 卷
页码：
收录情况： SCI
摘要： The Fibrinogen-related protein (FREP) gene family is a cornerstone of immune defense in metazoans, yet its evolution and functional specialization in invertebrates, particularly sea cucumbers, remain underexplored. By analyzing genomic data from 1004 species, this study reveals a significant and lineage-specific expansion of FREP genes in sea cucumbers. These genes are categorized into single-domain FREPs (sFREPs) and multi-domain FREPs (mFREPs), with the latter containing unique TIL domains associated with immune defense. Comparative analyses show that chromosomal rearrangements and gene duplications have driven FREP diversification, while transcriptomic profiling highlights tissue-specific expression and immune activation of TIL-containing mFREPs. These findings illuminate the adaptive evolution of FREPs and their pivotal role in pathogen recognition, emphasizing chromosomal dynamics and domain architecture in shaping invertebrate immunity. This study provides a foundation for deeper insights into the molecular basis of immune adaptation in sea cucumbers and other invertebrates.
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