Chemical Characterization of a Procyanidin-Rich Extract from Sorghum Bran and Its Effect on Oxidative Stress and Tumor Inhibition in Vivo
文献类型： 外文期刊
作者： Wu, Li 1 ; Huang, Zhaohui 1 ; Qin, Peiyou 1 ; Yao, Yang 1 ; Meng, Xianjun 3 ; Zou, Jianqiu 4 ; Zhu, Kai 4 ; Ren, Guixing 1 ;
作者机构： 1.Chinese Acad Agr Sci, Inst Crop Sci, Beijing 100081, Peoples R China
2.Sch Sci & Technol Qiongzhou Uivers, Hainan 572022, Peoples R China
3.Shenyang Agr Univ, Food Sci Coll, Shenyang 110161, Peoples R China
4.Liaoning Acad Agr Sci, Sorghum Res Inst, Shenyang 110161, Peoples R China
关键词： sorghum procyanidins;D-galactose;oxidative stress;VEGF;lung cancer;antitumor activity
期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.279； 五年影响因子：5.269 ）
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收录情况： SCI
摘要： The present study was to characterize a procyanidin-rich extract (PARE) from sorghum (Sorghum bicolor (L.) Moench) bran and assess its biological activities. The procyanidin oligomers were separated and identified by normal-phase HPLC equipped with fluorescence (ELD) and mass spectrometry (MS) detectors. In addition, the effects of PARE on oxidative stress in mice induced by D-galactose as well as tumor inhibition in CS7BL/6J mice bearing Lewis lung cancer were investigated. Administration of D-galactose significantly (p < 0.05) lowered the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). This was accompanied by a significant (p < 0.05) increase in malondialdehyde (MDA) levels in both liver and serum. Administration of PARE (150 mg/kg) significantly (p < 0.05) reversed the D-galactose-induced oxidative stress by enhancing the activities of antioxidant enzymes. Furthermore, PARE administration inhibited tumor growth and metastasis formation by suppressing vascular endothelial growth factor (VEGF) production. The results suggested that PARE had antioxidant and antitumor activities.
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