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ceRNA crosstalk mediated by ncRNAs is a novel regulatory mechanism in fish sex determination and differentiation

文献类型： 外文期刊

作者： Tang, Lili 1 ; Huang, Fei 3 ; You, Wuxin 4 ; Poetsch, Ansgar 5 ; Nobrega, Rafael Henrique 8 ; Power, Deborah Mary 9 ; Zhu, Tengfei 1 ; Liu, Kaiqiang 1 ; Wang, Hong-Yan 1 ; Wang, Qian 1 ; Xu, Xiwen 1 ; Feng, Bo 1 ; Schartl, Manfred 10 ; Shao, Changwei 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Key Lab Sustainable Dev Marine Fisheries, Minist Agr & Rural Affairs, Yellow Sea Fisheries Res Inst, Qingdao 266071, Shandong, Peoples R China

2.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Shandong, Peoples R China

3.Genosys Inc, Shenzhen 518000, Guangdong, Peoples R China

4.Nanchang Univ, NCU QMUL Joint Res Inst Precis Med Sci, Queen Mary Sch, Nanchang 330036, Peoples R China

5.Ocean Univ China, Coll Marine Life Sci, Qingdao 266003, Shandong, Peoples R China

6.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Biol & Biotechnol, Qingdao 266237, Shandong, Peoples R China

7.Ruhr Univ Bochum, Dept Plant Biochem, D-44801 Bochum, North Rhine Wes, Germany

8.Sao Paulo State Univ, Inst Biosci, Dept Struct & Funct Biol, Div Morphol,Reprod & Mol Biol Grp, BR-01049010 Botucatu, SP, Brazil

9.Univ Algarve, Ctr Marine Sci, Comparat Endocrinol & Integrat Biol, Campus Gambelas, P-8005139 Faro, Algarve, Portugal

10.Univ Wurzburg, Bioctr, Dev Biochem, D-97074 Wurzburg, Bayern, Germany

11.Texas State Univ, Xiphophorus Genet Stock Ctr, Dept Chem & Biochem, San Marcos, TX 78666 USA

期刊名称：GENOME RESEARCH （ 影响因子：9.438； 五年影响因子：13.537 ）

ISSN： 1088-9051

年卷期： 2022 年 32 卷 8 期

页码：

收录情况： SCI

摘要： Competing endogenous RNAs (ceRNAs) are vital regulators of gene networks in mammals. The involvement of noncoding RNAs (ncRNAs) as ceRNA in genotypic sex determination (GSD) and environmental sex determination (ESD) in fish is unknown. The Chinese tongue sole, which has both GSD and ESD mechanisms, was used to map the dynamic expression pattern of ncRNAs and mRNA in gonads during sex determination and differentiation. Transcript expression patterns shift during the sex differentiation phase, and ceRNA modulation occurs through crosstalk of differentially expressed long ncRNAs (lncRNAs), circular RNAs (circRNAs), microRNAs (miRNAs), and sex-related genes in fish. Of note was the significant up-regulation of a circRNA from the sex-determining gene dmrt1 (circular RNA dmrt1) and a lncRNA, called AMSDT (which stands for associated with male sex differentiation of tongue sole) in Chinese tongue sole testis. These two ncRNAs both share the same miRNA response elements with gsdf, which has an up-regulated expression when they bind to miRNA cse-miR-196 and concurrent down-regulated female sex-related genes to facilitate testis differentiation. This is the first demonstration in fish that ceRNA crosstalk mediated by ncRNAs modulates sexual development and unveils a novel regulatory mechanism for sex determination and differentiation.

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