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Old pesticide, new use: Smart and safe enantiomer of isocarbophos in locust control

文献类型： 外文期刊

作者： Kong, Yuan 1 ; Ji, Chenyang 2 ; Qu, Jianli 1 ; Chen, Yuanchen 1 ; Wu, Shenggan 3 ; Zhu, Xinkai 4 ; Niu, Lixi 4 ; Zhao, Me 1 ;

作者机构： 1.Zhejiang Univ Technol, Coll Environm, Key Lab Microbial Technol Ind Pollut Control Zhej, Hangzhou 310014, Peoples R China

2.Zhejiang Shuren Univ, Interdisciplinary Res Acad, Hangzhou 310015, Peoples R China

3.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, Hangzhou 310021, Peoples R China

4.Shanxi Univ, Natl Minist Educ, Key Lab Chem Biol & Mol Engn, Inst Biotechnol, Taiyuan 030006, Peoples R China

关键词： Locusta migratoria manilensis; Enantioselectivity; Acetylcholinesterase; Carboxylesterases; Glutathione S-transferases

期刊名称：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY （ 影响因子：6.291； 五年影响因子：6.393 ）

ISSN： 0147-6513

年卷期： 2021 年 225 卷

页码：

收录情况： SCI

摘要： Locust plagues are still worldwide problems. Selecting active enantiomers from current chiral insecticides is necessary for controlling locusts and mitigating the pesticide pollution in agricultural lands. Herein, two enantiomers of isocarbophos (ICP) were separated and the enantioselectivity in insecticidal activity against the pest Locusta migratoria manilensis (L. migratoria) and mechanisms were investigated. The significant difference of LD50 between (+)-ICP (0.609 mg/kg bw) and (-)-ICP (79.412 mg/kg bw) demonstrated that (+)-ICP was a more effective enantiomer. The enantioselectivity in insecticidal activity of ICP enantiomers could be attributed to the selective affinity to acetylcholinesterase (AChE). Results of in vivo and in vitro assays suggested that AChE was more sensitive to (+)-ICP. In addition, molecular docking showed that the -CDOKER energies of (+)-ICP and (-)-ICP were 25.6652 and 24.4169, respectively, which suggested a stronger affinity between (+)-ICP and AChE. Significant selectivity also occurred in detoxifying enzymes activities (carboxylesterases (CarEs) and glutathione S-transferases (GSTs)) and related gene expressions. Suppression of detoxifying enzymes activities with (+)-ICP treatment suggested that (-)-ICP may induce the detoxifying enzyme-mediated ICP resistance. A more comprehensive understanding of the enantioselectivity of ICP is necessary for improving regulation and risk assessment of ICP.

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