Metabolic perturbations in zebrafish ( Danio rerio ) larvae exposed to sulfentrazone and imidacloprid
文献类型： 外文期刊
作者： Wang, Feidi 1 ; Chen, Shuangshuang 2 ; Lv, Lu 1 ; Wu, Shenggan 1 ; Zhao, Yang 1 ; Liu, Xinju 1 ; Geng, Ningbo 2 ; Tang, Tao 1 ;
作者机构： 1.Zhejiang Acad Agr Sci, State Key Lab Managing Biot & Chem Threats Qual &, Key Lab Pesticide Residue Detect, Minist Agr & Rural Affairs,Inst Agroprod Safety &, Hangzhou 310021, Peoples R China
2.Chinese Acad Sci, CAS Key Lab Separat Sci Analyt Chem, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
3.Dalian Maritime Univ, Coll Environm Sci & Engn, Dalian 116026, Peoples R China
关键词： Combined toxicity; Metabolomics; Sulfentrazone; Imidacloprid
期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：9.8； 五年影响因子：9.6 ）
ISSN： 0048-9697
年卷期： 2024 年 933 卷
页码：
收录情况： SCI
摘要： The intensive and widespread application of pesticides in agroecosystems can lead to the simultaneous exposure of non-target aquatic organisms to insecticides and herbicides. However, the underlying mechanisms through which aquatic organisms undergo metabolic reprogramming to withstand the combined effects of the insecticide imidacloprid (IMI) and herbicide sulfentrazone (SUL) remain poorly elucidated. This study employs metabolomics to investigate the effects of individual and combined exposures to IMI and SUL on zebrafish (Danio rerio ), aiming to simulate complex environmental conditions. Metabolomics analysis revealed extensive metabolic reprogramming in larvae induced by the selected agrochemicals. Both individual and combined exposures disrupted nucleotide metabolism, inhibited glycolysis, and led to the accumulation of acetylcholine through the shared modulation of differential metabolites. Notably, individual exposure exhibited a unique mode of action. Larvae exposed to IMI alone showed mitochondrial dysfunction, potentially stemming from interference with the electron transport chain, while SUL-induced disruptions were associated with glycerophospholipid accumulation, marking it as a critical target. Additionally, calculations of the metabolic effect level index indicated antagonistic interactions between SUL and IMI mixtures at an overall metabolic level. The results obtained through investigating the lethal and sub -lethal effects also revealed that the simultaneous application of SUL and IMI may have the potential to diminish acute and developmental toxicity in zebrafish. This study underscores the significance of metabolomics as a valuable and effective strategy for deciphering the toxicity and interactions of agrochemical mixtures.
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