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Intra-species differences shape differences of enrofloxacin residues and its degradation products in tilapia: A precise risk assessment

文献类型： 外文期刊

作者： Zhu, Lei 1 ; Meng, Shunlong 1 ; Fang, Longxiang 1 ; Li, Zhonghua 1 ; Yang, Ruonan 7 ; Qiu, Liping 2 ; Zhong, Liqiang 3 ; Song, Chao 1 ;

作者机构： 1.Nanjing Agr Univ, Wuxi Fisheries Coll, Wuxi 214081, Peoples R China

2.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Wuxi 214081, Peoples R China

3.Freshwater Fisheries Res Inst Jiangsu Prov, Nanjing 210017, Peoples R China

4.Minist Agr & Rural Affairs, Lab Qual & Safety Risk Assessment Aquat Prod Envir, Wuxi 214081, Peoples R China

5.Minist Agr & Rural Affairs, Key Lab Control Qual & Safety Aquat Prod, Beijing 100141, Peoples R China

6.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Key Lab Freshwater Fisheries & Germplasm Resources, Minist Agr & Rural Affairs, Wuxi 214081, Peoples R China

7.Nanjing Normal Univ, Sch Food Sci & Pharmaceut Engn, Nanjing 210023, Peoples R China

关键词： Enrofloxacin; Residue; Degradation product; Intra-species difference; Risk assessment

期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：12.2； 五年影响因子：11.9 ）

ISSN： 0304-3894

年卷期： 2024 年 476 卷

页码：

收录情况： SCI

摘要： The increasing use and abuse of antibiotics in agriculture and aquaculture necessitates a more thorough risk assessment. We first advocate a precise assessment that subdivides the assessment scope from interspecies to intraspecific levels. Differences in ENR residues and degradation within the intraspecific category were simultaneously explored. This study chose red and GIFT tilapia, both belonging to the intra-specific category of tilapia, for an enrofloxacin (ENR) exposure experiment. Red tilapia had a lower area under the curve (AUC) representing drug accumulation, indicating a notably shorter withdrawal period (7 days) compared to GIFT tilapia (31.4 days) in the edible parts. While four potential transformation pathways were proposed for ENR in tilapia, red tilapia had fewer detected degradation products (6 items) than GIFT tilapia (10 items), indicating a simpler transformation pathway in red tilapia. Predictive assessments using the Toxtree model revealed that of the four extra degradation products in GIFT tilapia, two may possess carcinogenic and mutagenic properties. Overall, differences were observed in ENR residues and degradation within the intraspecific category, with red tilapia presenting lower risks than GIFT tilapia. This work suggests a new strategy to perfect the methodology for antibiotic risk assessment and facilitate systematic antibiotic administration management in the future.

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