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Comparative Study on Immune Function of the Head and Trunk Kidney in Rainbow Trout Responding to IHNV Infection

文献类型： 外文期刊

作者： Sun, Ruhan 1 ; Wang, Qin 1 ; Huang, Zhenyu 1 ; Zhan, Mengting 1 ; Zhao, Zhangchun 1 ; Wang, Bingchao 1 ; Guo, Mengge 1 ; Yuan, Le 2 ; Shi, Zechao 4 ; Ouyang, Gang 2 ; Ji, Wei 1 ;

作者机构： 1.Huazhong Agr Univ, Coll Fisheries, Dept Aquat Anim Med, Key Lab Freshwater Anim Breeding, Wuhan 430070, Peoples R China

2.Chinese Acad Sci, Inst Hydrobiol, Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China

3.Minist Agr, Key Lab Aquaculture Dis Control, Wuhan 430072, Peoples R China

4.Yangtze River Fisheries Res Inst, Chinese Acad Fishery Sci, Wuhan 430223, Peoples R China

关键词： head kidney; trunk kidney; immune; IHNV

期刊名称：VIRUSES-BASEL （ 影响因子：5.818； 五年影响因子：5.811 ）

ISSN：

年卷期： 2022 年 14 卷 12 期

页码：

收录情况： SCI

摘要： A teleost's kidney was divided into head kidney and trunk kidney. The head kidney is an important lymphatic organ, while the trunk kidney mainly performs osmotic pressure regulation and excretion functions. Previous studies have shown that the teleost's head kidney exerts a strong immune response against pathogen invasion, while the mechanism of immune response in the trunk kidney is still rarely reported. Therefore, in this study, we established an Infectious hematopoietic necrosis virus (IHNV) immersion infection model to compare the similarities and differences of immune response mechanisms between the head kidney and trunk kidney against viral infection. The results showed that IHNV infection causes severe tissue damage and inflammatory reaction in the head and trunk kidney, triggers a series of interferon cascade reactions, and produces strong immune response. In addition, the transcriptome data showed that the head kidney and trunk kidney had similar immune response mechanisms, which showed that the NOD-like receptor signaling pathway and Toll-like receptor signaling pathway were activated. In conclusion, despite functional differentiation, the teleost's trunk kidney still has a strong immune response, especially the interferon-stimulated genes, which have stronger immune response in the trunk kidney than in the head kidney when responding to IHNV infection. This study contributes to a more comprehensive understanding of the teleost immune system and enriches the theory of kidney immunity in teleosts.

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