您好，欢迎访问中国水产科学研究院 机构知识库！
中国水产科学研究院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Blood-brain barrier permeability and brain immunity in yellow catfish ( Pelteobagrus fulvidraco) responding to Edwardsiella ictaluri infection

文献类型： 外文期刊

作者： Wang, Qin 1 ; Shen, Li 2 ; Guo, Mengge 1 ; Wang, Bingchao 1 ; Liu, Huimin 1 ; Xiao, Ke 1 ; Shi, Zechao 2 ; Ji, Wei 1 ;

作者机构： 1.Huazhong Agr Univ, Coll Fisheries, Engn Res Ctr Green Dev Convent Aquat Biol Ind Yang, Minist Educ,Minist Agr & Rural Affair,Key Lab Fre, Wuhan 430070, Peoples R China

2.CAFS, Minist Agr & Rural Affairs China, Yangtze River Fisheries Res Inst, Key Lab Freshwater Biodivers Conservat, Wuhan 430223, Peoples R China

关键词： Blood-brain barrier; Edwardsiella ictaluri; Yellow catfish; Immunoglobulin

期刊名称：AQUACULTURE （ 影响因子：3.9； 五年影响因子：4.4 ）

ISSN： 0044-8486

年卷期： 2025 年 599 卷

页码：

收录情况： SCI

摘要： The blood-brain barrier (BBB) plays a crucial role in maintaining the homeostasis of the central nervous system (CNS) by preventing the entry of harmful substances into the brain parenchyma. Although bacterial infections of the CNS are typically linked to BBB disruption, there is a notable paucity of knowledge concerning alterations in BBB permeability and the CNS immune response in teleosts during such infections. This study investigates these phenomena by administering an intraperitoneal injection of Edwardsiella ictaluri to yellow catfish ( Pelteobagrus fulvidraco), followed by an evaluation of BBB permeability and the CNS immune response. E. ictaluri has the capability to penetrate the BBB and predominantly colonizes the mesencephalon region. Furthermore, there was a significant elevation in reactive oxygen species (ROS) activity within both the telencephalon and mesencephalon, accompanied by a reduction in mRNA expression levels of tight junction (TJ) proteins, which coincided with increased BBB permeability. Additionally, pathological alterations in brain tissue structure were observed following E. ictaluri infection.The immune response of the CNS was triggered by E. ictaluri infection, which primarily affected the functionality of the neuropeptide signaling pathway and chemokine activity. Notably, E. ictaluri infection resulted in a significant increase in the amount of B cells in the mesencephalon and elevated antibody levels. According to these findings, E. ictaluri enhanced the permeability of the BBB by rupturing the TJs between endothelial cells. This disruption induced inflammation and resulted in an increased presence of immunoglobulins and B cells within the CNS.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：中国水产科学研究院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台