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L-theanine relieves acute alcoholic liver injury by regulating the TNF-alpha/NF-kappa B signaling pathway in C57BL/6J mice

文献类型： 外文期刊

作者： Sun, Lingli 1 ; Wen, Shuai 1 ; Li, Qiuhua 1 ; Lai, Xingfei 1 ; Chen, Ruohong 1 ; Zhang, Zhenbiao 1 ; Li, Dongli 2 ; Sun, 1 ;

作者机构： 1.Guangdong Acad Agr Sci, Tea Res Inst, Guangdong Prov Key Lab Tea Plant Resources Innova, Guangzhou 510640, Peoples R China

2.Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529020, Peoples R China

3.Int Healthcare Innovat Inst Jiangmen, Jiangmen 529040, Peoples R China

关键词： L-theanine; Acute alcoholic liver injury; Anti-inflammation; TNF-alpha; NF-kappa B pathway

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：4.451； 五年影响因子：4.908 ）

ISSN： 1756-4646

年卷期： 2021 年 86 卷

页码：

收录情况： SCI

摘要： Acute alcoholic liver injury (AALI) refers to the inflammatory hepatic damage caused by alcohol. In severe cases, it can lead to steatohepatitis, alcoholic fibrosis and even cirrhosis. In this study, we analyzed the hepatoprotective activity of L-theanine on mice fed with a large amount of ethanol at one time, and the underlying molecular mechanism. The extensive liver injury caused by alcohol feeding was alleviated by L-theanine, which reduced tissue damage, decreased transaminase levels, and increased antioxidant activity. Mechanistically, Ltheanine downregulated phosphorylated NF-kappa B, TNF-alpha and IKK alpha in the liver tissues and the LO2 normal hepatocyte cell line, which in turn lowered secretion of iNOS, IL-1 beta and IL-6. Taken together, L-theanine prevents alcohol-induced liver inflammation by blocking the intrahepatic TNF-alpha/NF-kappa B pathway, and is a promising treatment strategy against AALI.

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