Genome-wide characterization of integrin (ITG) gene family and their expression profiling in half-smooth tongue sole (Cynoglossus semilaevis) upon Vibrio anguillarum infection
文献类型： 外文期刊
作者： Li, Zhujun 1 ; Tan, Suxu 1 ; Qi, Longjiang 1 ; Chen, Yadong 2 ; Liu, Hongning 1 ; Liu, Xinbao 1 ; Sha, Zhenxia 1 ;
作者机构： 1.Qingdao Univ, Inst Aquat Biotechnol, Coll Life Sci, Qingdao 266071, Peoples R China
2.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao 266071, Peoples R China
关键词： Integrins; Half-smooth tongue sole; Vibrio anguillarum; Immune
期刊名称：COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS （ 影响因子：3.0； 五年影响因子：3.2 ）
ISSN： 1744-117X
年卷期： 2023 年 47 卷
页码：
收录情况： SCI
摘要： Integrins (ITGs) are transmembrane heterodimer receptors with ITG & alpha; subunit and ITG & beta; subunit, participating in various physiological processes, including immunity. At present, systematic research on ITGs in teleost is scarce, especially in half-smooth tongue sole (Cynoglossus semilaevis). In this study, a set of 28 ITG genes in half-smooth tongue sole have been identified and characterized. The phylogenetic analysis showed that ITG & alpha; and ITG & beta; subunits were respectively classified into five and two clusters, consistent with previous studies. The selection pressure analysis indicated that most of ITG genes were under purifying selection, except for ITG & alpha;11b and ITG & alpha;L with positive selection. The expression profiles of eight selected ITG genes, including ITG & alpha;1, ITG & alpha;5, ITG & alpha;8, ITG & alpha;11, ITG & beta;1, ITG & beta;2, ITG & beta;3, and ITG & beta;8, were analyzed in healthy tissues and after infection with Vibrio anguillarum, revealed their implications in immune response. The study provided a comprehensive characterization and expression analysis of ITG genes in half-smooth tongue sole, setting a solid foundation for further functional studies and promising potential in disease control.
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