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Dietary resveratrol attenuation of intestinal inflammation and oxidative damage is linked to the alteration of gut microbiota and butyrate in piglets challenged with deoxynivalenol

文献类型： 外文期刊

作者： Qiu, Yueqin 1 ; Yang, Jun 1 ; Wang, Li 1 ; Yang, Xuefen 1 ; Gao, Kaiguo 1 ; Zhu, Cui 1 ; Jiang, Zongyong 1 ;

作者机构： 1.Guangdong Acad Agr Sci, State Key Lab Livestock & Poultry Breeding, Guangzhou 510640, Peoples R China

2.Guangdong Acad Agr Sci, Key Lab Anim Nutr & Feed Sci South China, Minist Agr & Rural Affairs, Guangzhou 510640, Peoples R China

3.Guangdong Acad Agr Sci, Guangdong Prov Key Lab Anim Breeding & Nutr, Guangzhou 510640, Peoples R China

4.Guangdong Acad Agr Sci, Maoming Branch, Guangdong Lab Lingnan Modern Agr, Inst Anim Sci, Guangzhou 510640, Peoples R China

5.South China Agr Univ, Coll Anim Sci, Guangzhou 510642, Peoples R China

6.Foshan Univ, Sch Life Sci & Engn, Foshan 528225, Peoples R China

关键词： Deoxynivalenol; Gut health; Gut microbiota; Inflammation; Oxidative damage; Piglets; Resveratrol

期刊名称：JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY （ 影响因子：5.032； 五年影响因子：5.922 ）

ISSN： 1674-9782

年卷期： 2021 年 12 卷 1 期

页码：

收录情况： SCI

摘要： Background Deoxynivalenol (DON) is a widespread mycotoxin that induces intestinal inflammation and oxidative stress in humans and animals. Resveratrol (RES) effectively exerts anti-inflammatory and antioxidant effects. However, the protective effects of RES on alleviating DON toxicity in piglets and the underlying mechanism remain unclear. Therefore, this study aimed to investigate the effect of RES on growth performance, gut health and the gut microbiota in DON-challenged piglets. A total of 64 weaned piglets [Duroc x (Landrace x Yorkshire), 21-d-old, 6.97 +/- 0.10 kg body weight (BW)] were randomly allocated to 4 treatment groups (8 replicate pens per treatment, each pen containing 2 males; n = 16 per treatment) for 28 d. The piglets were fed a control diet (CON) or the CON diet supplemented with 300 mg RES/kg diet (RES group), 3.8 mg DON/kg diet (DON) or both (DON+RES) in a 2 x 2 factorial design. Results DON-challenged piglets fed the RES-supplemented diet had significantly decreased D-lactate concentrations and tumor necrosis factor alpha (TNF-alpha) and interleukin 1 beta (IL-1 beta) mRNA and protein expression, and increased zonula occludens-1 (ZO-1) mRNA and protein expression compared with those of DON-challenged piglets fed the unsupplemented diet (P < 0.05). Compared with unsupplemented DON-challenged piglets, infected piglets fed a diet with RES showed significantly decreased malondialdehyde (MDA) levelsand increased mRNA expression of antioxidant enzymes and antioxidant genes (i.e., GCLC, GCLM, HO-1, SOD1 and NQO-1) and glutamate-cysteine-ligase modulatory subunit (GCLM) protein expression (P < 0.05). Moreover, RES supplementation significantly abrogated the increase in the proportion of TUNEL-positive cells and the protein expression of caspase3 in DON-challenged piglets (P < 0.05). Finally, RES supplementation significantly increased the abundance of Roseburia and butyrate concentrations, while decreasing the abundances of Bacteroides and unidentified-Enterobacteriaceae in DON-challenged piglets compared with DON-challenged piglets alone (P < 0.05). Conclusions RES supplementation improved gut health in DON-challenged piglets by strengthening intestinal barrier function, alleviating intestinal inflammation and oxidative damage, and positively modulating the gut microbiota. The protective effects of RES on gut health may be linked to increased Roseburia and butyrate concentrations, and decreased levels of Bacteroides and unidentified-Enterobacteriaceae.

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