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Campylobacter jejuni infection induces dynamic expression of avian host defense peptides in vitro and in vivo

文献类型： 外文期刊

作者： Li, Pengxiang 1 ; Cui, Yifang 2 ; Guo, Fangfang 2 ; Guo, Jiahui 1 ; Cao, Xiaoya 2 ; Lin, Jun 3 ; Ding, Baoan 1 ; Xu, Fuzhou 2 ;

作者机构： 1.Qinghai Univ, Coll Agr & Anim Husb, Dept Anim Sci, Xining 810016, Peoples R China

2.Beijing Acad Agr & Forestry Sci, Inst Anim Husb & Vet Med, Beijing Key Lab Prevent & Control Infect Dis Lives, Beijing, Peoples R China

3.Univ Tennessee, Dept Anim Sci, Knoxville, TN USA

4.Beijing Acad Agr & Forestry Sci, Inst Anim Husb & Vet Med, 9 Shuguang Huayuan Middle Rd, Beijing 100097, Peoples R China

关键词： Campylobacter jejuni; Avian host defense peptide; ?-defensin; Cathelicidin; Expression pattern

期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.3； 五年影响因子：3.5 ）

ISSN： 0378-1135

年卷期： 2023 年 277 卷

页码：

收录情况： SCI

摘要： Campylobacter jejuni is considered as the leading cause of worldwide foodborne bacterial gastroenteritis. Chicken is the main reservoir of C. jejuni. Avian innate immune responses to C. jejuni remain poorly defined. Chicken host defense peptides (HDPs) are the major components of avian innate immune system. This study aimed to char-acterize the chicken HDPs responses to C. jejuni in vitro and in vivo. In the HD11 macrophage cell line, the HDPs, including AvBD1-2, CATH1-3, AvBD7, AvBD4, and AvBD6, were relatively higher expressed in untreated cells, whereas the expressions were suppressed after C. jejuni infection. In contrast, C. jejuni infection significantly increased the expression of the lower expressed HDPs, such as AvBD3, AvBD5, AvBD8-14, and CATHB1, in untreated cells. In the chicken challenge experiment, the immune tissues of spleens and cecal tonsils were collected from C. jejuni-infected and uninfected chickens at 1, 3 and 15 day post inoculation (DPI). In spleens of C. jejuni-infected chickens, only AvBD14 expression was elevated at 1 DPI. The majority of avian HDPs were significantly up-regulated at 3 DPI and dramatically decreased to the levels of uninfected controls at 15 DPI. In chicken cecal tonsils, only AvBD9 and AvBD14 were significantly up-regulated at 1 DPI with C. jejuni infection. Collectively, C. jejuni infection induced dynamic expression of chicken HDPs in both macrophage HD11 and immune tissues of chickens. Suppression of chicken HDPs expression may be an evasion strategy of C. jejuni for persistent colonization in chicken intestine by circumventing the chicken immune system.

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