Impact of quorum sensing signaling molecules in gram-negative bacteria on host cells: current understanding and future perspectives
文献类型： 外文期刊
作者： Xiao, Yingping 1 ; Zou, Huicong 3 ; Li, Jingjing 3 ; Song, Tongxing 3 ; Lv, Wentao 1 ; Wang, Wen 1 ; Wang, Zhenyu 4 ; Tao, Shiyu 3 ;
作者机构： 1.Zhejiang Acad Agr Sci, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou, Peoples R China
2.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, Hangzhou, Peoples R China
3.Huazhong Agr Univ, Coll Anim Sci & Technol, Wuhan 430070, Peoples R China
4.China Agr Univ, Coll Anim Sci & Technol, State Key Lab Anim Nutr, Beijing, Peoples R China
关键词： Quorum sensing; gram-negative bacteria; signaling molecule; host cell; gut health
期刊名称：GUT MICROBES （ 影响因子：9.434； 五年影响因子：11.724 ）
ISSN： 1949-0976
年卷期： 2022 年 14 卷 1 期
页码：
收录情况： SCI
摘要： Quorum sensing is a molecular signaling-based communication mechanism in prokaryotes. In the basic mode, signaling molecules released by certain bacteria are sensed by intracellular receptors or membrane-bound receptors of other members in the community, leading to the collective isogenic signaling molecule synthesis and synchronized activities. This regulation is important for the symbiosis of the bacterium with the host, as well as virulence and biofilm formation. Notably, quorum sensing signaling molecules are not only able to control microbial community behavior but can likewise regulate the physiological status of host cells. Here, we provide a comprehensive review of the importance of quorum sensing signaling molecules in gram-negative bacteria in regulating host cell function and gut health, and suggest possible opportunities for application in combating human and animal diseases by blocking the pathways through which quorum sensing signaling molecules exert their functions.
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