The protective effect of licochalcone A against inflammation injury of primary dairy cow claw dermal cells induced by lipopolysaccharide
文献类型： 外文期刊
作者： Tian, Mengyue 1 ; Li, Nan 2 ; Liu, Ruonan 1 ; Li, Ke 1 ; Du, Jinliang 1 ; Zou, Dongmin 4 ; Ma, Yuzhong 1 ;
作者机构： 1.Hebei Agr Univ, Coll Vet Med, 2596 Lekai South St, Baoding 071001, Hebei, Peoples R China
2.Hebei Agr Univ, Coll Anim Sci & Technol, Baoding 071001, Hebei, Peoples R China
3.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Int Joint Res Lab Fish Immunopharmacol, Wuxi 214081, Jiangsu, Peoples R China
4.Shanxi Agr Univ, Coll Vet Med, Taigu 030801, Shanxi, Peoples R China
期刊名称：SCIENTIFIC REPORTS （ 影响因子：4.996； 五年影响因子：5.516 ）
ISSN： 2045-2322
年卷期： 2022 年 12 卷 1 期
页码：
收录情况： SCI
摘要： Laminitis is one of the most important and intractable diseases in dairy cows, which can lead to enormous economic losses. Although many scholars have conducted a large number of studies on laminitis, the therapeutic test of medicinal plants in vitro is really rare. Licochalcone A is proved to possess anti-inflammatory and anti-oxidant properties. But the effect of licochalcone A on LPS-induced inflammatory claw dermal cells has not been discovered yet. In this study, the primary dairy cow claw dermal cells were treated with gradient concentrations of licochalcone A (1, 5, 10 mu g/mL) in the presence of 10 mu g/mL lipopolysaccharides (LPS). The results indicated that licochalcone A reduced the concentrations of inflammation mediators (TNF-alpha, IL-1 beta and IL-6), increased the activity of SOD, reduced the levels of MDA and ROS, downregulated the mRNA expressions of TLR4 and MyD88, suppressed the protein levels of p-I kappa B alpha and p-p65, and upregulated the protein expression of PPAR gamma. In summary, licochalcone A protected dairy cow claw dermal cells against LPS-induced inflammatory response and oxidative stress through the regulation of TLR4/MyD88/NF-kappa B and PPAR gamma signaling pathways.
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