Long-term exposure to environmental level of phenanthrene causes adaptive immune response and fibrosis in mouse kidneys
文献类型： 外文期刊
作者： Ruan, Fengkai 1 ; Wu, Lifang 2 ; Yin, Hanying 1 ; Fang, Lu 1 ; Tang, Chen 1 ; Huang, Siyang 1 ; Fang, Longxiang 3 ; Zuo, 1 ;
作者机构： 1.Xiamen Univ, Hosp Xiamen 5, Affiliated Hosp 1,Xiangan Branch, Sch Life Sci,State Key Lab Cellular Stress Biol, Xiamen 361102, Fujian, Peoples R China
2.Shanghai Jiao Tong Univ, Shanghai Key Lab Tumor Microenvironm & Inflammat, Sch Med,Dept Biochem & Mol Cell Biol, Key Lab Cell Differentiat & Apoptosis,Natl Minist, Shanghai 200025, Peoples R China
3.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Wuxi 214081, Jiangsu, Peoples R China
关键词： Polycyclic aromatic hydrocarbons (PAHs); Chronic kidney injury; Immune disorder; T helper cell; ER stress; Mitochondrial dysfunction
期刊名称：ENVIRONMENTAL POLLUTION （ 影响因子：8.071； 五年影响因子：8.35 ）
ISSN： 0269-7491
年卷期： 2021 年 283 卷
页码：
收录情况： SCI
摘要： As ubiquitous, persistent organic pollutants, polycyclic aromatic hydrocarbons (PAHs) have adverse impacts on human health. Phenanthrene (Phe) is one of the most abundant PAHs in the environment. However, the long-term effects of exposure to environmental level of Phe on the kidneys and the potential mechanisms are unclear. T helper (Th) cells, a subtype of CD4(+) T cells that play a central role in the renal immune microenvironment. In this study, male mice were chronically exposed to 5, 50, and 500 ng/kg bw Phe every other day for total 210 days. Those results indicated that environmental Phe exposure caused kidney hypertrophy, injury and fibrosis in the mice. Chronic, long-term environmental level of Phe exposure did not significantly alter the innate immune response but induced adaptive immune response changes (Th1/Th2 related cytokines release), causing a type 1 immune response in the 5 ng/kg bw Phe group and a type 2 immune response in the high dose groups (50 and 500 ng/kg bw). This study provides novel insights into the roles of adaptive immune response in long-term PAH exposure-induced chronic kidney injury and fibrosis, which is beneficial for further understanding the potential health hazards of PAHs and providing new avenues for immune intervention strategies to alleviate PAHs toxicity. (C) 2021 Published by Elsevier Ltd.
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