The polysaccharides from the fruits of Lycium barbarum L. modify the gut community profile and alleviate dextran sulfate sodium-induced colitis in mice
文献类型： 外文期刊
作者： Zhou, Wangting 1 ; Kan, Xuhui 1 ; Chen, Guijie 1 ; Sun, Yi 1 ; Ran, Linwu 2 ; Yan, Yamei 3 ; Mi, Jia 3 ; Lu, Lu 3 ; Zeng, Xiaoxiong 1 ; Cao, Youlong 3 ;
作者机构： 1.Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China
2.Ningxia Med Univ, Lab Anim Ctr, Yinchuan 750004, Ningxia, Peoples R China
3.Ningxia Acad Agr & Forestry, Inst Wolfberry Engn & Technol, Yinchuan 750004, Ningxia, Peoples R China
关键词： Lycium barbarum L.; Polysaccharides; Colitis; Gut microbiota; Bifidobacterium longum subsp.infantis; Akkermansia muciniphila
期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.025； 五年影响因子：7.626 ）
ISSN： 0141-8130
年卷期： 2022 年 222 卷
页码：
收录情况： SCI
摘要： In the present study, the effects of a purified fraction of polysaccharides from the fruits of Lycium barbarum L. (LBPs), named LBPs-4, on the dextran sodium sulfate (DSS)-induced colitis in mice were evaluated. The results showed that LBPs-4 decreased disease activity index score, prevented colon shortening and reduced plasma levels of pro-inflammatory cytokines (tumor necrosis factor alpha (TNF-alpha), interferon gamma (IFN-gamma), monocyte chemoattractant protein-1 (MCP-1) and prostaglandin E2) in mice with colitis. LBPs-4 could increase the relative abundances of Akkermansia and Bifidobacterium in gut microbiota, and it also mitigated the intestinal barrier damage by upregulating the level of tight junction protein ZO-1 and the number of goblet cells in colon. Moreover, the results of in vitro culture indicated that the growth of Bifidobacterium longum subsp. infantis CCX 19042 was promoted by LBPs-4, whereas the culture media of LBPs-4 by Bacteroides ovatus with or without addition of mucin could enhance the growth of Akkermansia muciniphila. Collectively, these results suggested that LBPs-4 should be potential prebiotics for the treatment of colitis.
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