The polysaccharides from the fruits of Lycium barbarum L. modify the gut community profile and alleviate dextran sulfate sodium-induced colitis in mice
文献类型： 外文期刊
作者： Zhou, Wangting 1 ; Kan, Xuhui 1 ; Chen, Guijie 1 ; Sun, Yi 1 ; Ran, Linwu 2 ; Yan, Yamei 3 ; Mi, Jia 3 ; Lu, Lu 3 ; Zeng, Xiaoxiong 1 ; Cao, Youlong 3 ;
作者机构： 1.Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China
2.Ningxia Med Univ, Lab Anim Ctr, Yinchuan 750004, Ningxia, Peoples R China
3.Ningxia Acad Agr & Forestry, Inst Wolfberry Engn & Technol, Yinchuan 750004, Ningxia, Peoples R China
关键词： Lycium barbarum L.; Polysaccharides; Colitis; Gut microbiota; Bifidobacterium longum subsp.infantis; Akkermansia muciniphila
期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.025； 五年影响因子：7.626 ）
ISSN： 0141-8130
年卷期： 2022 年 222 卷
页码：
收录情况： SCI
摘要： In the present study, the effects of a purified fraction of polysaccharides from the fruits of Lycium barbarum L. (LBPs), named LBPs-4, on the dextran sodium sulfate (DSS)-induced colitis in mice were evaluated. The results showed that LBPs-4 decreased disease activity index score, prevented colon shortening and reduced plasma levels of pro-inflammatory cytokines (tumor necrosis factor alpha (TNF-alpha), interferon gamma (IFN-gamma), monocyte chemoattractant protein-1 (MCP-1) and prostaglandin E2) in mice with colitis. LBPs-4 could increase the relative abundances of Akkermansia and Bifidobacterium in gut microbiota, and it also mitigated the intestinal barrier damage by upregulating the level of tight junction protein ZO-1 and the number of goblet cells in colon. Moreover, the results of in vitro culture indicated that the growth of Bifidobacterium longum subsp. infantis CCX 19042 was promoted by LBPs-4, whereas the culture media of LBPs-4 by Bacteroides ovatus with or without addition of mucin could enhance the growth of Akkermansia muciniphila. Collectively, these results suggested that LBPs-4 should be potential prebiotics for the treatment of colitis.
- 相关文献
作者其他论文 更多>>
-
In vivo absorption and fecal excretion of polysaccharides from the fruits of Lycium barbarum L. in rats through fluorescence labeling
作者：Zhou, Wangting;Kan, Xuhui;Dong, Wei;Sun, Yi;Zeng, Xiaoxiong;Yan, Yamei;Mi, Jia;Lu, Lu;Cao, Youlong;Wang, Wei
关键词：Lycium barbarum polysaccharides; Fluorescence labeling; Absorption
-
Anthocyanins from Lycium ruthenicum Murray Prevent High-Fat Diet-Induced Obesity in Female Mice via Gut Microbiota-Related Bile Acids Metabolism
作者：Li, Hui;Zhang, Meng;Tan, Tingting;Li, Shiying;Ran, Linwu;Li, Hui;Zhang, Meng;Tan, Tingting;Li, Shiying;Ran, Linwu;Mi, Jia;Lu, Lu;Yan, Yamei
关键词：Lycium ruthenicum Murray; female obesity; gut microbiota; bile acid metabolism
-
Petunidin-3-O-[rhamnopyranosyl-(trans-p-coumaroyl)]-5-O-(β-D-glucopyranoside), the main anthocyanin from the fruits of Lycium ruthenicum murray, enhances the lifespan of Caenorhabditis elegans by activating DAF-16 and improving the gut microbiota
作者：Zhang, Kangzhi;Zhu, Jiahao;Liu, Peiyun;Guo, Renpeng;Zeng, Xiaoxiong;Yan, Yamei;Mi, Jia;Lu, Lu;Cao, Youlong;Yan, Yamei;Mi, Jia;Lu, Lu;Cao, Youlong
关键词：Lycium ruthenicum murray; Caenorhabditis elegans; Lifespan; Antioxidant; Resistance; DAF-16; Intestinal microbiota
-
In vivo absorption and excretion in rats and in vitro digestion and fermentation by the human intestinal microbiota of 2-O-β-
d -glucopyranosyl-l -ascorbic acid from the fruits of Lycium barbarum L作者：Dong, Wei;Peng, Yujia;Xu, Weiqi;Zhou, Wangting;Zeng, Xiaoxiong;Yan, Yamei;Mi, Jia;Lu, Lu;Cao, Youlong;Yan, Yamei;Mi, Jia;Lu, Lu;Cao, Youlong
关键词：
-
The polysaccharides from the fruits of Lycium barbarum ameliorate high-fat and high-fructose diet-induced cognitive impairment via regulating blood glucose and mediating gut microbiota
作者：Tian, Xinyi;Dong, Wei;Zhou, Wangting;Sun, Yi;Zeng, Xiaoxiong;Yan, Yamei;Lu, Lu;Mi, Jia;Cao, Youlong;Yan, Yamei;Lu, Lu;Mi, Jia;Cao, Youlong
关键词：Polysaccharides; Neuroinflammation; Blood glucose homeostasis; Gut microbiota; Short-chain fatty acids
-
Anthocyanins from Lycium ruthenicum Murray attenuates high-fat diet-induced hypercholesterolemia in ApoE-/- mice are related to the modulation of gut microbiota and the ratio of conjugated to unconjugated bile acids in fecal bile acid profile
作者：Zhang, Meng;Li, Hui;Tan, Tingting;Ran, Linwu;Lu, Lu;Mi, Jia;Yan, Yamei;Rehman, Abdul;Yan, Yamei;Ran, Linwu
关键词：bile acids; gut microbiota; hypercholesterolemia; Lycium ruthenicum Murray
-
Metabolite-based genome-wide association studies enable the dissection of the genetic bases of flavonoids, betaine and spermidine in wolfberry (Lycium)
作者：Zhao, Jianhua;An, Wei;Yin, Yue;Duan, Linyuan;Ren, Xiaoyue;Liang, Xiaojie;Wang, Yajun;Wan, Ru;Huang, Ting;Zhang, Bo;Li, Yanlong;Cao, Youlong;Xu, Yuhui;Li, Haoxia;Wang, Bin;Wang, Liping;Wang, Bi;Luo, Jie
关键词：Wolfberry; genome assembly; metabolite-based genome-wide association study; bioactivity metabolites; candidate gene
