The interaction of pterostilbene with Kelch-like ECH-associated protein 1 and its regulation on the nuclear factor erythroid 2-related factor 2/ antioxidant response element pathway
文献类型： 外文期刊
作者： Lv, Chengyu 1 ; Ma, Xinqi 2 ; Liang, Chengyu 2 ; Chen, Yihao 1 ; Qin, Fen 1 ; Zhou, Chuntian 3 ; Huang, Wei 1 ; Liu, Qing 1 ; Wang, Yongjun 1 ; Liu, Zhuo 1 ; Qin, Fengxian 1 ; Sun, Chang 1 ; Li, Tiezhu 1 ; Hou, Ligang 1 ;
作者机构： 1.Jilin Acad Agr Sci, Inst Agrofood Technol, 1363 Ecol St, Changchun 130033, Peoples R China
2.Yanbian Univ, Coll Agr, Yanji 133000, Peoples R China
3.Baotou Light Ind Vocat Tech Coll, Dept Dairy Agr & Anim Husb Engn, Baotou 014035, Peoples R China
关键词： Pterostilbene; Antioxidant; Keap1 protein; Nrf2-ARE pathway
期刊名称：PROCESS BIOCHEMISTRY （ 影响因子：4.4； 五年影响因子：4.2 ）
ISSN： 1359-5113
年卷期： 2023 年 132 卷
页码：
收录情况： SCI
摘要： Pterostilbene is a naturally occurring stilbene compound known for its anti-tumor effect. However, the molecular mechanism is still not explored well. Thus, the present work was designed to investigate the regulation effect of pterostilbene on the Nrf2-ARE pathway. The results of molecular docking showed that pterostilbene bound at the top of the central pore of the Keap1 Kelch domain, and the hydrogen bond and hydrophobic interactions were crucial for their stable binding. The western blot analysis confirmed that pterostilbene treatment promoted Nrf2 nuclear translocation. Reported gene assays confirmed the ARE luciferase activity of pterostilbene. RT-PCR and western blot assays showed that pterostilbene regulated the gene and protein expression of HO-1, NQO1, and GCLM. In vitro free radical scavenging assays have shown that pterostilbene can be effective in scavenging DPPH, ABTS, and hydroxyl radicals. In summary, pterostilbene activates the Nrf2-ARE pathway for exerting its bioactivities.
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