Magnolol-driven microbiota modulation elicits changes in tryptophan metabolism resulting in reduced skatole formation in pigs
文献类型： 外文期刊
作者： Li, Yuanfei 1 ; Liu, Yanchen 1 ; Mu, Chunlong 3 ; Zhang, Changyi 4 ; Yu, Miao 1 ; Tian, Zhimei 1 ; Deng, Dun 1 ; Ma, Xianyong 1 ;
作者机构： 1.Guangdong Acad Agr Sci, Inst Anim Sci, Guangdong Engn Technol Res Ctr Anim Meat Qual & Sa, State Key Lab Swine & Poultry Breeding Ind,Key La, Guangzhou 510640, Peoples R China
2.Nanchang Normal Univ, Inst Biol Technol, Jiangxi Prov Key Lab Poultry Genet Improvement, Nanchang 330032, Peoples R China
3.AgResearch, Food Informat, Te Ohu Rangahau Kai, Palmerston North 4474, New Zealand
4.Univ Illinois Champaign Urbana, Carl R Woese Inst Genom Biol, Urbana, IL 61801 USA
5.Guangdong Acad Agr Sci, Inst Anim Sci, 1 Dafeng St,Wushan Rd, Guangzhou 510640, Guangdong, Peoples R China
关键词： Skatole production; Magnolol; Tryptophan; Skatole-producing pathway; Growing pigs
期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：13.6； 五年影响因子：12.7 ）
ISSN： 0304-3894
年卷期： 2024 年 467 卷
页码：
收录情况： SCI
摘要： Skatole of gut origin has garnered significant attention as a malodorous pollutant due to its escalating emissions, recalcitrance to biodegradation and harm to animal and human health. Magnolol is a health -promoting polyphenol with potential to considerably mitigate the skatole production in the intestines. To investigate the impact of magnolol and its underlying mechanism on the skatole formation, in vivo and in vitro experiments were conducted in pigs. Our results revealed that skatole concentrations in the cecum, colon, and faeces decreased by 58.24% (P = 0.088), 44.98% (P < 0.05) and 43.52% (P < 0.05), respectively, following magnolol supplementation. Magnolol supplementation significantly decreased the abundance of Lachnospira, Faecalibacterium, Paramuribaculum, Faecalimonas, Desulfovibrio, Bariatricus, and Mogibacterium within the colon (P < 0.05). Moreover, a strong positive correlation (P < 0.05) between skatole concentration and Desulfovibrio abundance was observed. Subsequent in silico studies showed that magnolol could dock well with indolepyruvate decarboxylase (IPDC) within Desulfovibrio. Further in vitro investigation unveiled that magnolol addition led to less indole-3pyruvate diverted towards the oxidative skatole pathway by the potential docking of magnolol towards IPDC, thereby diminishing the conversion of substrate into skatole. Our findings offer novel targets and strategies for skatole emission from the source.
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