Magnolol Supplementation Alters Serum Parameters, Immune Homeostasis, Amino Acid Profiles, and Gene Expression of Amino Acid Transporters in Growing Pigs
文献类型： 外文期刊
作者： Liu, Yanchen 1 ; Li, Yuanfei 2 ; Yu, Miao 2 ; Tian, Zhimei 2 ; Deng, Jinping 1 ; Ma, Xianyong 2 ; Yin, Yulong 1 ;
作者机构： 1.South China Agr Univ, Inst Subtrop Anim Nutr & Feed, Guangdong Prov Key Lab Anim Nutr Control, Natl Engn Res Ctr Breeding Swine Ind,Coll Anim Sci, Guangzhou 510642, Peoples R China
2.Guangdong Acad Agr Sci, Inst Anim Sci, State Key Lab Swine & Poultry Breeding Ind, Guangzhou 510640, Peoples R China
3.Minist Agr & Rural Affairs, Key Lab Anim Nutr & Feed Sci South China, Guangzhou 510640, Peoples R China
4.Guangdong Acad Agr Sci, Inst Anim Sci, Guangdong Prov Key Lab Anim Breeding & Nutr, Guangzhou 510640, Peoples R China
5.Guangdong Acad Agr Sci, Inst Anim Sci, Guangdong Engn Technol Res Ctr Anim Meat Qual & Sa, Guangzhou 510640, Peoples R China
6.Nanchang Normal Univ, Inst Biol Technol, Nanchang 330032, Peoples R China
关键词： magnolol; polyphenol; amino acid; arginine uptake; immune; pigs
期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：5.6； 五年影响因子：6.2 ）
ISSN： 1661-6596
年卷期： 2023 年 24 卷 18 期
页码：
收录情况： SCI
摘要： This study investigated whether dietary supplementation with magnolol affects growth performance, anti-inflammatory abilities, serum and muscle amino acid profiles, and metabolisms in growing pigs. A total of 42 seventy-days-old growing barrows (Duroc x Landrace x Yorkshire) were randomly allocated into two dietary groups: Con, control group (basal diet); and Mag, magnolol group (basal diet supplemented with 400 mg/kg of magnolol). The results revealed that dietary supplementation with magnolol had no effect (p > 0.05) on growth performance. However, magnolol supplementation remarkably increased (p < 0.05) the serum content of albumin, total protein, immunoglobulin G, immunoglobulin M, and interleukin-22. In addition, dietary magnolol supplementation altered the amino acid (AA) profiles in serum and dorsal muscle and particularly increased (p < 0.05) the serum content of arginine and muscle glutamate. Simultaneously, the mRNA expression of genes associated with AA transport in jejunum (SLC38A2, SLC1A5, and SLC7A1) and ileum (SLC1A5 and SLC7A1) was higher (p < 0.05) in the Mag group than in the Con group. Additionally, the serum metabolomics analysis showed that the addition of magnolol significantly enhanced (p < 0.05) arginine biosynthesis, as well as D-glutamine and D-glutamate metabolism. Overall, these results suggested that dietary supplementation with magnolol has the potential to improve the accumulation of AAs, protein synthesis, immunity, and body health in growing pigs by increasing intestinal absorption and the transport of AAs.
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