Immunomodulatory effects of the polysaccharide from Sinonovacula constricta on RAW264.7 macrophage cells
文献类型： 外文期刊
作者： Liu, Zhidong 1 ; Liu, Zhifang 1 ; Li, Laihao 2 ; Zhang, Junjie 3 ; Zhao, Qiancheng 4 ; Lin, Na 1 ; Zhong, Wenzhu 5 ; Jiang, Mei 1 ;
作者机构： 1.Chinese Acad Fishery Sci, East China Sea Fishery Res Inst, 300 Jungong Rd, Shanghai 200090, Peoples R China
2.Chinese Acad Fishery Sci, South China Sea Fishery Res Inst, Guangzhou, Peoples R China
3.Jiangsu Ocean Univ, Coll Food Sci & Engn, Lianyungang, Peoples R China
4.Dalian Ocean Univ, Coll Food Sci & Engn, Dalian, Peoples R China
5.Chinese Acad Fishery Sci, Fishery Machinery & Instrument Res Inst, Shanghai, Peoples R China
关键词： immunomodulatory activity; macrophage; polysaccharide; Sinonovacula constricta
期刊名称：FOOD SCIENCE & NUTRITION （ 影响因子：3.553； 五年影响因子：3.634 ）
ISSN： 2048-7177
年卷期： 2022 年 10 卷 4 期
页码：
收录情况： SCI
摘要： This study aimed to evaluate the immunomodulatory effect of the polysaccharide from Sinonovacula constricta (SCP-1-1) in RAW264.7 cells, SCP-1-1 with a molecular weight of 440.0 kDa consisted of glucose and mannose. The immunomodulatory assay results showed that SCP-1-1 could significantly enhance phagocytic ability, NO production, and some cytokines (TNF-alpha, IL-6, and IL-1 beta) secretion of RAW264.7 cell in a dose-dependent manner. Western blot analysis results demonstrated that SCP-1-1 could regulate the expression levels of the key proteins in the signaling pathways of RAW264.7 cell and might associated with NF-kappa beta and P13K signaling pathway. These findings could contribute to elucidate the immunomodulatory activities of the polysaccharide from Sinonovacula constricta.
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