您好，欢迎访问中国水产科学研究院 机构知识库！
中国水产科学研究院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Joint toxicity mechanisms of binary emerging PFAS mixture on algae (Chlorella pyrenoidosa) at environmental concentration

文献类型： 外文期刊

作者： Liu, Xianglin 1 ; Zheng, Xiaowei 1 ; Zhang, Liangliang 1 ; Li, Jue 1 ; Li, Yanyao 2 ; Huang, Honghui 3 ; Fan, Zhengqiu 1 ;

作者机构： 1.Fudan Univ, Dept Environm Sci & Engn, Shanghai 200438, Peoples R China

2.Univ Ghent, Dept Green Chem & Technol, Lab Ind Water & Ecotechnol, B-8500 Kortrijk, Belgium

3.Chinese Acad Fishery Sci, South China Sea Fisheries Res Inst, Guangzhou 510300, Peoples R China

4.Guangdong Prov Key Lab Fishery Ecol & Environm, Guangzhou 510300, Peoples R China

关键词： Inhibition effect; Toxicity; Synergetic effect; Transcriptome; Biological pathway

期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：14.224； 五年影响因子：12.984 ）

ISSN： 0304-3894

年卷期： 2022 年 437 卷

页码：

收录情况： SCI

摘要： Since traditional Per-and polyfluoroalkyl substances (PFAS) were banned in 2009 due to their bioaccumulation, persistence and biological toxicity, the emerging PFAS have been widely used as their substitutes and entered the aquatic environment in the form of mixtures. However, the joint toxicity mechanisms of these emerging PFAS mixtures to aquatic organisms remain largely unknown. Then, based on the testing of growth inhibition, cytotoxicity, photosynthesis and oxidative stress, and the toxicity mechanism of PFAS mixture (Perfluorobutane sulfonate and Perfluorobutane sulfonamide) to algae was explored using the Gene set enrichment analysis (GSEA). The results revealed that all three emerging PFAS treatments had a certain growth inhibitory effect on Chlorella pyrenoidosa (C. pyrenoidosa), but the toxicity of PFAS mixture was stronger than that of individual PFAS and showed a significant synergistic effect at environmental concentration. The joint toxicity mechanisms of binary PFAS mixture to C. pyrenoidosa were related to the damage of photosynthetic system, obstruction of ROS metabolism, and inhibition of DNA replication. Our findings are conductive to adding knowledge in understanding the joint toxicity mechanisms and provide a basis for assessing the environmental risk of emerging PFAS.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：中国水产科学研究院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台