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Structural characterization and bioactivities of a novel polysaccharide obtained from Lachnum YM38 together with its zinc and selenium derivatives

文献类型： 外文期刊

作者： He, Yaling 1 ; Chen, Hui 2 ; Ye, Ziyang 1 ; Zhang, Xinmiao 1 ; Ye, Hongling 3 ; Ye, Ming 1 ;

作者机构： 1.Hefei Univ Technol, Engn Res Ctr Bioproc, Sch Food & Biol Engn, Hefei 230009, Peoples R China

2.Shanghai Acad Agr Sci, Inst Edible Fungi, Shanghai 201403, Peoples R China

3.Anqing Vocat & Tech Coll, Sch Agr Forestry & Fash Technol, Anqing 246003, Peoples R China

关键词： Lachnum polysaccharide; Zinc and selenium modification; Structural characterization; Bioactivities

期刊名称：PROCESS BIOCHEMISTRY （ 影响因子：4.885； 五年影响因子：4.43 ）

ISSN： 1359-5113

年卷期： 2022 年 122 卷

页码：

收录情况： SCI

摘要： To prepare zinc and selenium modified polysaccharides derivatives (ZnLEP-1a and SeLEP-1a), a novel poly-saccharide (LEP-1a) isolated from Lachnum YM38 was chosen. Following that, the structural characterization and in vitro bioactivities of LEP-1, ZnLEP-1a and SeLEP-1a were investigated. Results revealed that LEP-1a had a molecular weight of 5.69 x 104 Da and was composed of mannose, galactose and glucose. The linkage types of LEP-1a were proved to be (1 ->)-alpha-D-Manp, (1 -> 3)-alpha-D-Manp, (1 -> 2)-alpha-D-Galp, (1 -> 2)-alpha-D-Glcp, (1 -> 2,6)-alpha-D-Manp. Zinc content of ZnLEP-1a was 0.69 mg/g, while selenium content of SeLEP-1a was 206.99 mu g/g. Compared with LEP-1a, ZnLEP-1a and SeLEP-1a had a lower molecular weight, same monosaccharides in different molar ratios. The results of FT-IR, DSC, NMR, SEM and AFM suggested that there were obvious changes in structural characteristics after LEP-1a was modified with zinc and selenium. ZnLEP-1a and SeLEP-1a had stronger anti-oxidant, hypoglycemic, antitumor activities in vitro in comparison with LEP-1a. As a result, ZnLEP-1a and SeLEP-1a showed great potential to develop into a natural antioxidant, hypoglycemic and low-toxic antitumor drug.

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