The M35 Metalloprotease Effector FocM35_1 Is Required for Full Virulence of Fusarium oxysporum f. sp. cubense Tropical Race 4
文献类型： 外文期刊
作者： Zhang, Xiaoxia 1 ; Huang, Huoqing 2 ; Wu, Bangting 2 ; Xie, Jianghui 3 ; Viljoen, Altus 4 ; Wang, Wei 3 ; Mostert, Dia 1 ;
作者机构： 1.Shenyang Agr Univ, Coll Biosci & Biotechnol, Shenyang 110866, Peoples R China
2.Guangdong Acad Agr Sci, Inst Fruit Tree Res,Minist Agr, Key Lab South Subtrop Fruit Biol & Genet Resource, Key Lab Trop & Subtrop Fruit Tree Res Guangdong P, Guangzhou 510640, Peoples R China
3.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Haikou 571101, Hainan, Peoples R China
4.Univ Stellenbosch, Dept Plant Pathol, ZA-7602 Matieland, South Africa
5.Guangxi Acad Agr Sci, Inst Plant Protect, Guangxi Key Lab Biol Crop Dis & Insect Pests, Nanning 530007, Peoples R China
关键词： Fusarium wilt; banana; virulence; effector; metalloprotease
期刊名称：PATHOGENS （ 影响因子：3.492； 五年影响因子：4.066 ）
ISSN：
年卷期： 2021 年 10 卷 6 期
页码：
收录情况： SCI
摘要： Fusarium oxysporum f. sp. cubense tropical race 4 (Foc TR4) causes Fusarium wilt of banana, the most devastating disease on a banana plant. The genome of Foc TR4 encodes many candidate effector proteins. However, little is known about the functions of these effector proteins on their contributions to disease development and Foc TR4 virulence. Here, we discovered a secreted metalloprotease, FocM35_1, which is an essential virulence effector of Foc TR4. FocM35_1 was highly upregulated during the early stages of Foc TR4 infection progress in bananas. The FocM35_1 knockout mutant compromised the virulence of Foc TR4. FocM35_1 could interact with the banana chitinase MaChiA, and it decreased banana chitinase activity. FocM35_1 induced cell death in Nicotiana benthamiana while suppressing the INF1-induced hypersensitive response (HR), and its predicted enzymatic site was required for lesion formation and the suppression to INF1-induced HR on N. benthamiana leaves. Importantly, treatment of banana leaves with recombinant FocM35_1 accelerates Foc TR4 infection. Collectively, our study provides evidence that metalloprotease effector FocM35 seems to contribute to pathogen virulence by inhibiting the host immunity.
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