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Increases in Cellular Immune Responses Due to Positive Effect of CVC1302-Induced Lysosomal Escape in Mice

文献类型： 外文期刊

作者： Yu, Xiaoming 1 ; Zhang, Yuanyuan 1 ; Hou, Liting 1 ; Qiao, Xuwen 1 ; Zhang, Yuanpeng 1 ; Cheng, Haiwei 1 ; Lu, Haiyan 1 ; Chen, Jin 1 ; Du, Luping 1 ; Zheng, Qisheng 1 ; Hou, Jibo 1 ; Tong, Guangzhi 5 ;

作者机构： 1.Jiangsu Acad Agr Sci, Inst Vet Immunol & Engn, Nanjing 210014, Peoples R China

2.Jiangsu Acad Agr Sci, Natl Res Ctr Engn & Technol Vet Biol, Nanjing 210014, Peoples R China

3.Minist Sci & Technol, Jiangsu Key Lab Food Qual & Safety, State Key Lab Cultivat Base, Nanjing 210014, Peoples R China

4.Guo Tai Taizhou Ctr Technol Innovat Vet Biol, Taizhou 225300, Peoples R China

5.Shanghai Vet Res Inst, Chinese Acad Agr Sci, Shanghai 200241, Peoples R China

关键词： cross-presentation; cellular immunity; cytosolic pathways; lysosomal escape

期刊名称：VACCINES （ 影响因子：7.8； 五年影响因子：7.4 ）

ISSN：

年卷期： 2023 年 11 卷 11 期

页码：

收录情况： SCI

摘要： This study found a higher percentage of CD8+ T cells in piglets immunized with a CVC1302-adjuvanted inactivated foot-and-mouth disease virus (FMDV) vaccine. We wondered whether the CVC1302-adjuvanted inactivated FMDV vaccine promoted cellular immunity by promoting the antigen cross-presentation efficiency of ovalbumin (OVA) through dendritic cells (DCs), mainly via cytosolic pathways. This was demonstrated by the enhanced levels of lysosomal escape of OVA in the DCs loaded with OVA and CVC1302. The higher levels of ROS and significantly enhanced elevated lysosomal pH levels in the DCs facilitated the lysosomal escape of OVA. Significantly enhanced CTL activity levels was observed in the mice immunized with OVA-CVC1302. Overall, CVC1302 increased the cross-presentation of exogenous antigens and the cross-priming of CD8+ T cells by alkalizing the lysosomal pH and facilitating the lysosomal escape of antigens. These studies shed new light on the development of immunopotentiators to improve cellular immunity induced by vaccines.

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