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Analysis of CVC1302-Mediated Enhancement of Monocyte Recruitment in Inducing Immune Responses

文献类型： 外文期刊

作者： Lu, Haiyan 1 ; Yu, Xiaoming 1 ; Hou, Liting 1 ; Zhang, Yuanpeng 1 ; Li, Lan 1 ; Qiao, Xuwen 1 ; Cheng, Haiwei 1 ; Du, Luping 1 ; Chen, Jin 1 ; Zheng, Qisheng 1 ; Hou, Jibo 1 ;

作者机构： 1.Jiangsu Acad Agr Sci, Inst Vet Immunol & Engn, Nanjing 210014, Peoples R China

2.Jiangsu Acad Agr Sci, Natl Res Ctr Engn & Technol Vet Biol, Nanjing 210014, Peoples R China

3.Minist Sci & Technol, Jiangsu Key Lab Food Qual & Safety, State Key Lab Cultivat Base, Nanjing 210014, Peoples R China

4.Guo Tai Taizhou Ctr Technol Innovat Vet Biol, Taizhou 210014, Peoples R China

5.Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Peoples R China

关键词： CVC1302; monocyte; CXCL9; CXCL10; antigen

期刊名称：VACCINES （ 影响因子：7.8； 五年影响因子：7.4 ）

ISSN：

年卷期： 2024 年 12 卷 1 期

页码：

收录情况： SCI

摘要： Monocytes (Mos) are believed to play important roles during the generation of immune response. In our previous study, CVC1302, a complex of PRRs agonists, was demonstrated to recruit Mo into lymph nodes (LNs) in order to present antigen and secret chemokines (CXCL9 and CXCL10), which attracted antigen-specific CD4+ T cells. As it is known that Mos in mice are divided into two main Mo subsets (Ly6C+ Mo and Ly6C- Mo), we aimed to clarify the CVC1302-recruiting Mo subset and functions in the establishment of immunity. In this study, we found that CVC1302 attracted both Ly6C+ Mo and Ly6C- Mo into draining LNs, which infiltrated from different origins, injection muscles and high endothelial venule (HEV), respectively. We also found that the numbers of OVA+ Ly6C+ Mo in the draining LNs were significantly higher compared with OVA+ Ly6C- Mo. However, the levels of CXCL9 and CXCL10 produced by Ly6C- Mo were significantly higher than Ly6C+ Mo, which plays important roles in attracting antigen-specific CD4+ T cells. Under the analysis of their functions in initiating immune responses, we found that the ability of the Ly6C+ monocyte was mainly capturing and presenting antigens, otherwise; the ability of the Ly6C- monocyte was mainly secreting CXCL9 and CXCL10, which attracted antigen-specific CD4+ T cells through CXCR3. These results will provide new insights into the development of new immunopotentiators and vaccines.

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