您好，欢迎访问广东省农业科学院 机构知识库！
广东省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Shibi Tea (Adinandra nitida) and Camellianin A Alleviate CCl4-Induced Liver Injury in C57BL-6J Mice by Attenuation of Oxidative Stress, Inflammation, and Apoptosis

文献类型： 外文期刊

作者： Chen, Ruohong 1 ; Lian, Yingyi 2 ; Wen, Shuai 1 ; Li, Qiuhua 1 ; Sun, Lingli 1 ; Lai, Xingfei 1 ; Zhang, Zhenbiao 1 ; Zhu, Junquan 3 ; Tang, Linsong 4 ; Xuan, Ji 5 ; Yuan, Erdong 2 ; Sun, Shili 1 ;

作者机构： 1.Guangdong Acad Agr Sci, Guangdong Key Lab Tea Resources Innovat & Utiliza, Tea Res Inst, Guangzhou 510640, Peoples R China

2.South China Univ Technol, Engn Res Ctr Starch & Plant Prot Deep Proc, Guangdong Prov Key Lab Green Proc Nat Prod & Prod, Sch Food Sci & Engn,Minist Educ, Guangzhou 510641, Peoples R China

3.Guangdong Soc Plant Protect, Guangzhou 510640, Peoples R China

4.Taihongyuan Agr Co Ltd, Xinyi 525000, Maoming, Peoples R China

5.Hosp South China Univ Technol, Guangzhou 510641, Peoples R China

关键词： Adinandra nitida (Theaceae); Camellianin A; liver injury; oxidative stress; inflammation; anti-apoptosis

期刊名称：NUTRIENTS （ 影响因子：6.706； 五年影响因子：7.185 ）

ISSN：

年卷期： 2022 年 14 卷 15 期

页码：

收录情况： SCI

摘要： Liver injury is a significant public health issue nowadays. Shibi tea is a non-Camellia tea prepared from the dried leaves of Adinandra nitida, one of the plants with the greatest flavonoid concentration, with Camellianin A (CA) being the major flavonoid. Shibi tea is extensively used in food and medicine and has been found to provide a variety of health advantages. The benefits of Shibi tea and CA in preventing liver injury have not yet been investigated. The aim of this study was to investigate the hepatoprotective effects of extract of Shibi tea (EST) and CA in mice with carbon tetrachloride (CCl4)-induced acute liver injury. Two different concentrations of EST and CA were given to model mice by gavage for 3 days. Treatment with two concentrations of EST and CA reduced the CCl4-induced elevation of the liver index, liver histopathological injury score, alanine aminotransferase (ALT), and aspartate aminotransferase (AST). Western blotting and immunohistochemical analysis demonstrated that EST and CA regulated the oxidative stress signaling pathway protein levels of nuclear factor E2-related factor 2 (Nrf2)/heme-oxygenase-1 (HO-1), the expression of inflammatory cytokines, the phosphorylated nuclear factor-kappaB p65 (p-NF-kappa B)/nuclear factor-kappaB p65 (NF-kappa B) ratio, the phospho-p44/42 mitogen-activated protein kinase (p-MAPK), and the apoptosis-related protein levels of BCL2-associated X (Bax)/B cell leukemia/lymphoma 2 (Bcl2) in the liver. Taken together, EST and CA can protect against CCl4-induced liver injury by exerting antioxidative stress, anti-inflammation, and anti-apoptosis.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：广东省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台