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Electro-assembly of ss-chitin nanofibers to construct oriented cryogel for wound healing

文献类型： 外文期刊

作者： Guo, Xiaojia 1 ; Shi, Xiaowen 1 ; Chen, Lingyun 2 ; Wang, Lan 3 ; Deng, Hongbing 1 ; Du, Yumin 1 ;

作者机构： 1.Wuhan Univ, Hubei Engn Ctr Nat Polymers Based Med Mat, Hubei Biomass Resource Chem & Environm Biotechnol, Hubei Int Sci & Technol Cooperat Base Sustainable, Wuhan 430079, Peoples R China

2.Univ Alberta, Dept Agr Food & Nutr Sci, Edmonton, AB T6G 2P5, Canada

3.Hubei Acad Agr Sci, Inst Agroprod Proc & Nucl Agr Technol, Key Lab Agr Prod Cold Chain Logist, Minist Agr & Rural Affairs, Wuhan 430064, Peoples R China

关键词： ss-chitin nanofibers; Electroassembly; Hydrogel; Oriented structure; Wound healing

期刊名称：CHEMICAL ENGINEERING JOURNAL （ 影响因子：15.1； 五年影响因子：14.3 ）

ISSN： 1385-8947

年卷期： 2023 年 471 卷

页码：

收录情况： SCI

摘要： The construction of natural polymeric nanocomponents with tunable hierarchical structure in a simple and controllable process remains a great challenge. Herein, an oriented ss-chitin nanofiber hydrogel was fabricated by an electro-assembly process in water phase, during which the internal structure of the hydrogel was facilely tuned by the process parameters. The orientation of the ss-chitin nanofibers hydrogel was influenced by the concentration of nanofibers and pH, and strengthened by increased current density and longer deposition time. Cryogels with extraordinary physical and biological properties were subsequently obtained by freeze drying. When used as wound dressing in cell and animal models, the oriented ss-chitin nanofiber cryogels could significantly promote cell proliferation and accelerate wound healing, outperforming the healing effect of unoriented structure.

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