Cinnamaldehyde affects lipid droplets metabolism after adipogenic differentiation of C2C12 cells
文献类型： 外文期刊
作者： Liu, Yanrong 1 ; Liu, Zhengqun 1 ; Luo, Qiang 1 ; Sun, Zhuwen 1 ; Li, Ning 1 ; Zheng, Zi 1 ; Mu, Shuqin 1 ; Zhou, Xiaoqiao 4 ; Yan, Jun 1 ; Sun, Chao 2 ; Zhang, Hongfu 3 ;
作者机构： 1.Tianjin Acad Agr Sci, Inst Anim Husb & Vet, Tianjin 300381, Peoples R China
2.Northwest A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Shaanxi, Peoples R China
3.Chinese Acad Agr Sci, Inst Anim Sci, State Key Lab Anim Nutr, Beijing 100193, Peoples R China
4.Qingdao Agr Univ, Coll Anim Sci & Technol, Qingdao 266109, Peoples R China
5.Shaanxi Prov Livestock Technol Promot Stn, Xian 710000, Shaanxi, Peoples R China
关键词： Cinnamaldehyde; Adipogenic differentiation; Lipid droplets; Metabolism
期刊名称：MOLECULAR BIOLOGY REPORTS （ 影响因子：2.8； 五年影响因子：2.7 ）
ISSN： 0301-4851
年卷期： 2022 年
页码：
收录情况： SCI
摘要： Background Based on our previous research conducted on cinnamaldehyde (CA) exhibiting its ability to improve the growth performance of fattening pigs and the adipogenesis induction model of C2C12 cells constructed in our laboratory, we explored the effects of CA on the generation and development of lipid droplets (LDs) in adipogenic differentiated C2C12 cells. Methods and results C2C12 cells were treated with either 0.4 mM or 0.8 mM CA. BODIPY staining and triglyceride measurements were conducted to observe the morphology of LDs, and Western blotting was used to measure the expression of their metabolism-related proteins. The results showed that the average number of LDs in the CA treatment groups was more than the control group (P < 0.05), whereas the average LD size and triglyceride content decreased (P < 0.05). Compared with the control group, the expression levels of fusion-related genes in the LDs of the CA treatment group significantly decreased, while decomposition-related genes and autophagy-related genes in the LDs in C2C12 cells significantly increased (P < 0.01). Conclusion Cinnamaldehyde promoted the decomposition and autophagy of lipid droplets in C2C12 cells and inhibited the fusion of lipid droplets.
- 相关文献
作者其他论文 更多>>
-
Adiponectin attenuates H2O2-induced apoptosis in chicken skeletal myoblasts through the lysosomal-mitochondrial axis
作者：Wang, Han;Li, Chi;Zhu, Longbo;Liu, Zhengqun;Li, Ning;Zheng, Zi;Liang, Shiyue;Yan, Jun;Wang, Han;Li, Chi;Zhu, Longbo
关键词：Adiponectin; Apoptosis; Mitochondrial; Lysosomal; Skeletal myoblasts
-
Baicalin restore intestinal damage after early-life antibiotic therapy: the role of the MAPK signaling pathway
作者：Zhang, Shunfen;Tang, Shanlong;Liu, Zhengqun;Zhong, Ruqing;Chen, Liang;Zhang, Hongfu;Zhang, Shunfen;Lv, Huiyuan;Cai, Xueying;Liu, Zhengqun;Lv, Huiyuan
关键词：Baicalin; Intestinal damage; Energy metabolism; Calcium signaling pathway; MAPK signaling pathway
-
Ammonia exposure-triggered redox imbalance with the occurrence of inflammatory response, cell apoptosis, and the circadian clock disturbance leads to lung injury in growing pigs
作者：Tang, Shanlong;Liu, Zhengqun;Deng, Fuli;Xu, Ye;Zhong, Ruqing;Chen, Liang;Zhang, Hongfu;Liu, Zhengqun
关键词：Ammonia; Oxidative stress; Inflammation; Apoptosis; Circadian clock
-
Prediction equations of the metabolizable energy in corn developed by chemical composition and enzymatic hydrolysate gross energy for roosters
作者：Li, Kai;Bai, Guosong;Teng, Chunran;Liu, Lei;Zhong, Ruqing;Chen, Liang;Zhang, Hongfu;Liu, Zhengqun;Yan, Honglin;Zhou, Jianchuan
关键词：metabolizable energy; enzymatic hydrolysate gross energy; prediction equation; corn; rooster
-
Biocontrol activities of grey mould of grapes with the volatile organic compounds generated by yeast HXMG-1 isolated from grapes
作者：Li, Ning;Wang, Bujiang;Cui, Xinyi;Hou, Jing;Zhang, Na
关键词：Biocontrol activities; Yeast; Volatile organic compounds; Botrytis cinerea
-
Effect of dulcitol on growth performance, antioxidant activity, immune function, and intestinal microflora of growing-finishing pigs
作者：Liu, Zhengqun;Liang, Shiyue;Zheng, Zi;Li, Ning;Zhang, Chunhua;Yan, Jun;Li, Qianjun;Mu, Shuqin;Wang, Diankui;Liu, Renmin;He, Pei
关键词：Dulcitol; Growth performance; Nutrients digestibility; Serum indices; Fecal microbiota; Growing-finishing pigs
-
Time-course effects of different fiber-rich ingredients on energy values, microbiota composition and SCFA profile in growing pigs
作者：Gao, Qingtao;Liu, Zhengqun;Li, Kai;Bai, Guosong;Liu, Lei;Zhong, Ruqing;Chen, Liang;Zhang, Hongfu;Liu, Zhengqun
关键词：Adaptation time; Energy value; Fecal microbiota; Fiber -rich ingredient; Growing pig
