Mechanism and regulation of mitophagy in nonalcoholic fatty liver disease (NAFLD): A mini-review
文献类型： 外文期刊
作者： Zhu, Lihui 1 ; Wu, Xiao 2 ; Liao, Rongrong 1 ;
作者机构： 1.Shanghai Acad Agr Sci, Inst Anim Husb & Vet Sci, Shanghai 201106, Peoples R China
2.Shanghai Acad Agr Sci, Biotechnol Res Inst, Key Lab Agr Genet & Breeding, Shanghai 201106, Peoples R China
3.2901 Beidi Rd, Shanghai 201106, Peoples R China
关键词： Autophagy; Metabolism; Traditional Chinese medicine; Fatty liver disease; Lipid
期刊名称：LIFE SCIENCES （ 影响因子：6.1； 五年影响因子：5.8 ）
ISSN： 0024-3205
年卷期： 2023 年 312 卷
页码：
收录情况： SCI
摘要： Mitochondrial dysfunction has been hypothesized to play a central role in the pathobiology of nonalcoholic fatty liver disease (NAFLD). Thus, maintenance of mitochondria homeostasis and function is important for NAFLD treatment. Mitophagy, a process that selectively clears damaged or dysfunctional mitochondria through auto-phagic machinery, is beneficial for mitochondrial homeostasis. Notably, strategies that regulate mitophagy exert beneficial effects in preclinical experiments. Traditional Chinese medicine (TCM) is a natural product including active ingredients, extracts, and has great potential in the prevention and treatment of liver diseases. Given the importance of mitophagy, this review summarizes mitophagy-related pathways and the latest findings on the regulation of mitophagy in NAFLD. We also highlight the potential of TCM targeting mitophagy for the treatment
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