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Genomic Dissection of Chinese Yangtze River Delta White Goat Based on Whole Genome Sequencing

文献类型： 外文期刊

作者： Gao, Jun 1 ; Sun, Lingwei 1 ; Liao, Rongrong 1 ; Lyu, Yuhua 1 ; Zhang, Shushan 1 ; Xu, Jiehuan 1 ; He, Mengqian 1 ; Wu, Caifeng 1 ; Zhang, Defu 1 ; Lin, Yuexia 1 ; Dai, Jianjun 1 ;

作者机构： 1.Shanghai Acad Agr Sci, Inst Anim Sci & Vet Med, Shanghai 201106, Peoples R China

2.Shanghai Municipal Key Lab Agrigenet & Breeding, Shanghai 201106, Peoples R China

3.Minist Agr & Rural Affairs, Key Lab Livestock & Poultry Resources Evaluat & Ut, Shanghai 201106, Peoples R China

关键词： Chinese Yangtze River Delta white goat; whole genome sequencing; selective sweep analysis

期刊名称：ANIMALS （ 影响因子：2.7； 五年影响因子：3.2 ）

ISSN： 2076-2615

年卷期： 2025 年 15 卷 7 期

页码：

收录情况： SCI

摘要： The conservation and utilization of livestock genetic resources is essential for the maintenance of biodiversity and breed innovation. Whole genome sequencing (WGS) was performed on 90 samples from Chinese Yangtze River Delta White goats (YRD), sourced from two populations of Chongming island white goats and Haimen white goats, aiming to dissect their genomic characteristics. In addition, 262 WGS data from nine other breeds of goats were downloaded from the NCBI database. These WGS data obtained were used to identify and analyze genetic variation with the goat reference genome, and the genetic structure of goat populations was analyzed. Through selective sweep analysis, the selection-signature genes and their polymorphic features were identified. It was found that the most significant genomic selection region in YRD goats was in the region of 62.9-64.6 Mb on chromosome 13, which contained genes related to the coat color and muscle growth of the goats. Nucleotide diversity of MYH7B, a gene related to the development of the goat's skeletal muscle, within the Yangtze River Delta white goat population was significantly lower than in other domestic and foreign goat breeds, suggesting that the gene was subject to selection. In addition, the IGF2BP2 gene, reported to be associated with litter size in goats, showed clear selection-signature characteristics in the Boer goats compared to the YRD goats.

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