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Expression profile of long non-coding RNAs in porcine lymphnode response to porcine circovirus type 2 infection

文献类型： 外文期刊

作者： Yang, Keli 1 ; Dong, Ling 4 ; Duan, Zhengying 1 ; Guo, Rui 1 ; Zhou, Danna 1 ; Liu, Zewen 1 ; Liang, Wan 1 ; Liu, Wei 1 ; Yu 1 ;

作者机构： 1.Minist Agr & Rural Affairs, Key Lab Prevent & Control Agents Anim Bacteriosis, Wuhan 430064, Peoples R China

2.Hubei Acad Agr Sci, Inst Anim Husb & Vet, Wuhan 430064, Peoples R China

3.Hubei Prov Key Lab Anim Pathogen Microbiol, Wuhan 430064, Hubei, Peoples R China

4.Huazhong Agr Univ, Coll Anim Sci & Vet Med, Wuhan 430070, Hubei, Peoples R China

关键词： PCV2; lncRNA; RNA-seq; Lymphnode; Expression

期刊名称：MICROBIAL PATHOGENESIS （ 影响因子：3.738； 五年影响因子：3.664 ）

ISSN： 0882-4010

年卷期： 2021 年 158 卷

页码：

收录情况： SCI

摘要： Porcine circovirus type 2 (PCV2) can cause various clinical diseases in pigs, resulting in huge losses for the pig farms all over the world. In order to develop a new strategy to control PCV2, it is essential to understand its mechanisms firstly, especially PCV2 interferes with the host's innate immunity. In the present study, lncRNA and mRNA expression profiles in porcine lymphnode response to PCV2 infection were deeply sequenced and analyzed. 3271 novel lncRNAs were identified in all. 1898 mRNAs and 282 lncRNAs showed differential expression between control and PCV2-infected groups. The bioinformatics analysis including lncRNA-mRNA coexpression network construction, as well as GO and KEGG pathway analysis focused on the DEGs was carried out. The results indicated that lncRNAs might participate in PCV2 infection-induced the pathogenesis of immunosuppression through regulating the host's immune responses, biological regulation, response to stimulus, cellular component organization or biogenesis and metabolism. And these differentially expressed lncRNAs might play important roles in response to PCV2 infection in the host's innate immune system. These findings provided a large-scale survey of dysregulated lncRNAs after PCV2 infection, especially the lncRNAs responded to host's innate immune within the lymphnode. This study will provide a novel insight into the lncRNAs' functions and the possible immunosuppressive mechanism induced by PCV2 infection. However, further research will be required to verify the characteristic function of the dysregulated lncRNAs.

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