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Antimicrobial resistance and virulence genes of Streptococcus agalactiae isolated from mastitis milk samples in China

文献类型： 外文期刊

作者： Zhao, Yankun 1 ; Shao, Wei 4 ; Wang, Fulan 1 ; Ma, Jiaoxiao 1 ; Chen, He 1 ; Wang, Shuai 1 ; Wu, Yating 1 ; Wang, Cheng 1 ; Zheng, Nan 5 ; Wang, Jiaqi 5 ; Liu, Huimin 5 ;

作者机构： 1.Xinjiang Acad Agr Sci, Inst Qual Stand & Testing Technol Agroprod, Beijing 830091, Peoples R China

2.Minist Agr & Rural Affairs, Lab Qual & Safety Risk Assessment Agroprod, Beijing 830091, Peoples R China

3.Key Lab Agroprod Qual & Safety Xinjiang, Xinjiang 830091, Peoples R China

4.Xinjiang Agr Univ, Coll Anim Sci, Xinjiang 830052, Peoples R China

5.Chinese Acad Agr Sci, Inst Anim Sci, Minist Agr Lab Qual & Safety Risk Assessment Dairy, Beijing 100193, Peoples R China

关键词： cattle; bovine mastitis; dairy industry; antimicrobial stewardship; virulence gene

期刊名称：JOURNAL OF VETERINARY RESEARCH （ 影响因子：2.058； 五年影响因子：1.948 ）

ISSN： 2450-7393

年卷期： 2022 年 66 卷 4 期

页码：

收录情况： SCI

摘要： Introduction: Streptococcus agalactiae is an important zoonotic pathogen that affects milk production and quality and poses a threat to public health. Treatment of infections with this bacterium exploits antimicrobials, to which the resistance of S. agalactiae is a growing problem. Addressing the possibility of a correlation between this pathogen's genetic factors for antimicrobial resistance and virulence, this study attempted to identify the relevant genes. Material and Methods: Antimicrobial resistance of S. agalactiae isolated from 497 Chinese bovine mastitic milk samples was detected by the broth microdilution method. Eight drug resistance genes and eleven virulence genes were detected using PCR. Results: Streptococcus agalactiae was 100% susceptible to rifampicin and vancomycin, 93.33% susceptible to sulfisoxazole and sulfamethoxazole, but 100% resistant to >= 3 of the 16 antimicrobial agents, thereby being multidrug resistant, with resistance to oxacillin, tetracycline, erythromycin, clindamycin, and gentamicin being common. The ermB, ermA and lnuA genes were carried by 73.33%, 66.67% and 60.00% of the strains, respectively. The carriage rates of the glnA, clyE, hylB, bibA, iagA, and fbsA virulence genes were greater than 40%, lmb and bac were not observed in any strain, and glnA+hylB+bibA+iagA+fbsA+clyE combined virulence gene patterns were the most commonly detected. Conclusion: Antimicrobial resistance of S. agalactiae is still a great concern for cattle health in China, and multidrug resistance coupled with the high positive rates of this bacterium's strains for virulence genes indicates the importance of S. agalactiae surveillance and susceptibility tests.

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