Characterization of caspase gene family in Sebastes schlegelii and their expression profiles under Aeromonas salmonicida and Vibrio anguillarum infection
文献类型： 外文期刊
作者： Yu, Haohui 1 ; Yan, Xu 2 ; Wang, Ningning 1 ; Liu, Xiantong 1 ; Xue, Ting 1 ; Li, Chao 1 ; Zhang, Xiaoyan 1 ;
作者机构： 1.Qingdao Agr Univ, Sch Marine Sci & Engn, Qingdao 266109, Peoples R China
2.Chinese Acad Fishery Sci, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao Natl Lab Marine Sci & Technol, Yellow Sea Fisheries Res Inst, Qingdao 266071, Peoples R China
3.Qingdao Univ, Coll Life Sci, Qingdao 266071, Peoples R China
关键词： Caspase gene family; Sebastes schlegelii; Characterizations; Expression patterns
期刊名称：COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY （ 影响因子：2.2； 五年影响因子：2.3 ）
ISSN： 1096-4959
年卷期： 2024 年 270 卷
页码：
收录情况： SCI
摘要： The caspase, functioning as a proteinase, plays a crucial role in eukaryotic cell apoptosis, regulation of apoptosis, cellular growth, differentiation, and immunity. The identification of caspase gene family in Sebastes schlegelii is of great help to understand its antimicrobial research. In S. schlegelii, we totally identified nine caspase genes, including four apoptosis initiator caspases (caspase 2, caspase 8, caspase 9 and caspase 10), four apoptosis executioners (caspase 3a, caspase 3b, caspase 6, and caspase 7) and one inflammatory executioner (caspase 1). The duplication of caspase 3 genes on chr3 and chr8 may have been facilitated by whole genome duplication (WGD) events or other complex evolutionary processes. In general, the number of caspase genes relatively conserved in high vertebrates, while exhibiting variation in teleosts. Furthermore, syntenic analysis and phylogenetic relationships analysis supported the correct classification of these caspase gene family in S. schlegelii, especially for genes with duplicated copies. Additionally, the expression patterns of these caspase genes in different tissues of S. schlegelii under healthy conditions were assessed. The results revealed that the expression levels of most caspase genes were significantly elevated in the intestine, spleen, and liver. To further investigate the potential immune functions of these caspase genes in S. schlegelii, we challenged individuals with A. salmonicida and V. anguillarum, respectively. After infection with A. salmonicida, the expression levels of caspase 1 in the liver and spleen of S. schlegelii remained consistently elevated throughout the infection time points. The expression levels of most caspase family members in the intestine exhibited significant divergence following V. anguillarum infection. This study provides a comprehensive understanding of the caspase gene families in S. schlegelii, thereby establishing a solid foundation for further investigations into the functional roles of these caspase genes.
- 相关文献
作者其他论文 更多>>
-
Establishment of recombinant doubled haploid lines of Japanese flounder and evaluation of their reproductive capacity
作者：Zhang, Xiaoyan;Wang, Guixing;San, Lize;Zhang, Yitong;He, Zhongwei;Liu, Yufeng;Ren, Yuqin;Wang, Yufen;Hou, Jilun;Zhang, Xiaoyan;Wang, Guixing;San, Lize;Zhang, Yitong;He, Zhongwei;Liu, Yufeng;Ren, Yuqin;Wang, Yufen;Hou, Jilun
关键词：Recombinant doubled haploid; Japanese flounder; Reproductive traits; Gynogenesis; Targeted breeding
-
The first case of gynogenesis induced by cold- and heat-shock treatment in Thamnaconus modestus
作者：Zhang, Xiaoyan;San, Lize;Yang, Yucong;Tao, Yuehong;Ren, Jiangong;Liu, Yufeng;He, Zhongwei;Di, Jiashuo;Pei, Ziteng;Wang, Guixing;Hou, Jilun;Zhang, Xiaoyan;San, Lize;Yang, Yucong;Tao, Yuehong;Ren, Jiangong;Liu, Yufeng;He, Zhongwei;Di, Jiashuo;Pei, Ziteng;Wang, Guixing;Hou, Jilun;Di, Jiashuo;Pei, Ziteng
关键词：Thamnaconus modestus; Meiotic gynogenesis; Molecular markers; Homogeneity
-
Comprehensive analysis of circRNA-miRNA-mRNA networks in the kidney of snakehead (Channa argus) response to Nocardia seriolae challenge
作者：Zhang, Xiaoyan;Yu, Haohui;Wang, Ningning;Liu, Xiantong;Cao, Min;Li, Chao;Jiang, Yanliang
关键词：Snakehead(Channaargus); Nocardia seriolae; Kidney; circRNA-miRNA-mRNA networks; Immune response
-
Growth arrest and DNA damage-inducible 45 ab gene targeted by miR-20b-5p executes the inflammation and apoptosis by regulating MAPK and NF-κB pathways in black rockfish
作者：Gao, Chengbin;Cai, Xin;Zhu, Ying;Cao, Min;Li, Chao;Gao, Chengbin;Cai, Xin;Ma, Le;Sun, Peng
关键词：Ss _ gadd45ab; Inflammation; Apoptosis; Black rockfish; Regulatory mechanism
-
Manipulated C5aR1 over/down-expression associates with IL-6 expression during bacterial inflammation in half-smooth tongue sole (Cynoglossus semilaevis)
作者：Wu, Zhendong;Zang, Shaoqing;Wang, Wenwen;Tan, Suxu;Xu, Qian;Han, Sen;Ma, Jie;Shi, Kunpeng;Wang, Ningning;Sha, Zhenxia;Wang, Ningning;Sha, Zhenxia;Chen, Xuejie;Cheng, Jiayu
关键词：C5aR1; IL-6; Cynoglossus semilaevis; Bacterial inflammation; Vibrio anguillarum; Mycobacterium marinum
-
Regulatory mechanism of miR-722 on C5aR1 and its functions against bacterial inflammation in half-smooth tongue sole (Cynoglossus semilaevis)
作者：Liu, Hongning;Tan, Suxu;Liu, Xinbao;Li, Zhujun;Wang, Ningning;Han, Sen;Wu, Zhendong;Ma, Jie;Shi, Kunpeng;Wang, Wenwen;Sha, Zhenxia;Wang, Ningning;Chen, Yadong;Chen, Xuejie
关键词：Half-smooth tongue sole; Vibrio anguillarum; miR-722; C5aR1; Immune
-
Comparative Transcriptome Analysis of Spleen Reveals Potential Regulation of Genes and Immune Pathways Following Administration of Aeromonas salmonicida subsp. masoucida Vaccine in Atlantic Salmon (Salmo salar)
作者：Fu, Qiang;Li, Yuqing;Zhang, Hao;Cao, Min;Gao, Chengbin;Cai, Xin;Chen, Defeng;Yang, Ziying;Yang, Ning;Li, Chao;Zhang, Lu;Li, Jie
关键词：Aeromonas salmonicida; Atlantic salmon; Vaccination; Spleen; RNA-seq
