文献类型： 外文期刊
作者： Yang, Xin 1 ; Triboulet, Robinson 1 ; Liu, Qi 1 ; Sendinc, Erdem 1 ; Gregory, Richard I. 1 ;
作者机构： 1.Boston Childrens Hosp, Div Hematol Oncol, Stem Cell Program, Boston, MA 02115 USA
2.Harvard Med Sch, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA
3.Harvard Med Sch, Dept Pediat, Boston, MA 02115 USA
4.Harvard Stem Cell Inst, Cambridge, MA 02138 USA
5.Harvard Initiat RNA Med, Boston, MA 02115 USA
6.Twentyeight Seven Therapeut, Watertown, MA 02472 USA
7.Guangdong Acad Agr Sci, Rice Res Inst, Guangzhou 510640, Peoples R China
8.Guangdong Key Lab New Technol Rice Breeding, Guangzhou 510640, Peoples R China
期刊名称：NATURE COMMUNICATIONS （ 影响因子：16.6； 五年影响因子：17.0 ）
ISSN：
年卷期： 2022 年 13 卷 1 期
页码：
收录情况： SCI
摘要： N6-methyladenosine (m(6)A), the most abundant modification of mRNA, is essential for normal development and dysregulation promotes cancer. m(6)A is highly enriched in the 3' untranslated region (UTR) of a large subset of mRNAs to influence mRNA stability and/or translation. However, the mechanism responsible for the observed m(6)A distribution remains enigmatic. Here we find the exon junction complex shapes the m(6)A landscape by blocking METTL3-mediated m(6)A modification close to exon junctions within coding sequence (CDS). Depletion of EIF4A3, a core component of the EJC, causes increased METTL3 binding and m(6)A modification of short internal exons, and sites close to exon-exon junctions within mRNA. Reporter gene experiments further support the role of splicing and EIF4A3 deposition in controlling m(6)A modification via the local steric blockade of METTL3. Our results explain how characteristic patterns of m(6)A mRNA modification are established and uncover a role of the EJC in shaping the m(6)A epitranscriptome.
- 相关文献
作者其他论文 更多>>
-
Assessment of selective breeding effects and selection signatures in Qingyuan partridge chicken and its strains
作者：Kong, Shaofen;Cai, Bolin;Li, Xiaojing;Zhou, Zhen;Fang, Xiang;Yang, Xin;Cai, Danfeng;Nie, Qinghua;Kong, Shaofen;Cai, Bolin;Zhou, Zhen;Fang, Xiang;Yang, Xin;Cai, Danfeng;Nie, Qinghua;Kong, Shaofen;Cai, Bolin;Zhou, Zhen;Fang, Xiang;Yang, Xin;Cai, Danfeng;Nie, Qinghua;Kong, Shaofen;Cai, Bolin;Zhou, Zhen;Fang, Xiang;Yang, Xin;Cai, Danfeng;Nie, Qinghua;Luo, Xuehui;Guo, Suyin
关键词：Qingyuan partridge chicken; whole-genome resequencing; selective breeding; selection signatures; SNP
-
Rhodopseudomonas palustris shapes bacterial community, reduces Cd bioavailability in Cd contaminated flooding paddy soil, and improves rice performance
作者：Su, Yanqiu;Su, Yanqiu;Li, Ziyuan;Deng, Hongmei;Zhou, Qian;Li, Lihuan;Zhao, Lanyin;Shi, Qiuyun;Chen, Yanger;Yuan, Shu;Liu, Qi
关键词：Photosynthetic bacteria; Rhodopseudomonas palustris; Cadmium; Oryza sativa L.; Anaerobic bacteria
-
The tRNA Gm18 methyltransferase TARBP1 promotes hepatocellular carcinoma progression via metabolic reprogramming of glutamine
作者：Shi, Xiaoyan;Zhang, Yangyi;Wang, Yuci;Wang, Ruiqi;Xiong, Minggang;Cao, Yanlan;Chen, Hao;Shi, Xiaoyan;Zhang, Yangyi;Wang, Yuci;Wang, Ruiqi;Xiong, Minggang;Cao, Yanlan;Chen, Hao;Wang, Jie;Wang, Liyong;Ma, Honghui;Cai, Jiabin;Gao, Yang;Gao, Yang;Xiong, Minggang;Ou, Ningjing;Liu, Qi;Liu, Qi;Ma, Honghui
关键词：
-
m3C32 tRNA modification controls serine codon-biased mRNA translation, cell cycle, and DNA-damage response
作者：Cui, Jia;Sendinc, Erdem;Liu, Qi;Kim, Sujin;Fang, Jaden Y.;Gregory, Richard I.;Cui, Jia;Sendinc, Erdem;Liu, Qi;Kim, Sujin;Fang, Jaden Y.;Gregory, Richard I.;Liu, Qi;Liu, Qi;Gregory, Richard I.;Gregory, Richard I.;Gregory, Richard I.
关键词：
-
Dilemma between yield and quality: Multigenerational effect of elevated CO2 and nitrogen supply on wheat cultivars
作者：Wang, Xizi;Liang, Kehao;Liu, Fulai;Yang, Xin;Li, Shenglan;Li, Xiangnan;Liu, Fulai
关键词：biomass; CO2 enrichment; minerals; multiple generations; nitrogen supply; wheat
-
Does constant or changing light give the best rooting of hibiscus cuttings of two sizes?
作者：Yang, Xin;Yang, Xin;Li, Shenglan;Yang, Xin;Li, Shenglan;Liu, Fulai;Rosenqvist, Eva
关键词：Hibiscus; Rooting of cuttings; Cutting size; Changing light regimes; Light integral; Photosynthesis; Carbohydrates
-
Gaussian manifold metric learning for hyperspectral image dimensionality reduction and classification
作者：Xu, Zhi;Jiang, Zelin;Zhao, Longyang;Li, Shu;Liu, Qi
关键词：hyperspectral image; dimensionality reduction; graph embedding; metric learning; manifold learning
