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Pathogenicity, infective dose and altered gut microbiota in piglets infected with porcine deltacoronavirus

文献类型： 外文期刊

作者： Li, Jizong 1 ; Zhou, Jinzhu 1 ; Zhao, Shuqing 1 ; Guo, Rongli 1 ; Zhong, Chunyan 1 ; Xue, Tao 2 ; Peng, Qi 1 ; Zhang, Baotai 1 ; Fan, Baochao 1 ; Liu, Chuanmin 1 ; Ni, Yanxiu 1 ; Ren, Lili 6 ; Zhu, Xing 5 ; Li, Bin 1 ;

作者机构： 1.Jiangsu Acad Agr Sci, Inst Vet Med, Key Lab Vet Biol Engn & Technol,Minist Sci & Tech, Minist Agr,Jiangsu Key Lab Food Qual & Safety,Sta, Nanjing 210014, Peoples R China

2.Linyi Univ, Sch Pharm, Linyi 276000, Shandong, Peoples R China

3.Jiangsu Univ, Sch Food & Biol Engn, Inst Life Sci, Zhenjiang 212013, Jiangsu, Peoples R China

4.Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Peoples R China

5.Guizhou Univ, Coll Anim Sci, Guiyang 550025, Peoples R China

6.Nanjing Tech Univ, Sch Pharm, Nanjing 21009, Peoples R China

7.Southwest Guizhou Vocat & Tech Coll Nationalities, Biol Engn Dept, Xingyi 562400, Peoples R China

8.Yangzhou Univ, Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou 225009, Jiangsu, Peoples R China

关键词： Porcine deltacoronavirus; Pathogenicity; 16S rRNA sequencing; Gut microbiota

期刊名称：VIROLOGY （ 影响因子：3.513； 五年影响因子：3.479 ）

ISSN： 0042-6822

年卷期： 2022 年 567 卷

页码：

收录情况： SCI

摘要： Porcine deltacoronavirus (PDCoV) is an emerging swine enteropathogenic coronavirus that cause severe diarrhea, resulting in high mortality in neonatal piglets. Little is known regarding the pathogenicity of PDCoV in different infective dose and the dynamic changes in the composition of the gut microbiota in PDCoV-induced diarrhea piglets. In this study, 5-day-old piglets were experimentally infected with different dose of PDCoV. The challenged piglets developed typical symptoms, characterized by acute and severe watery diarrhea from 1 to 8 days post-inoculation (DPI), and viral shedding was detected in rectal swab until 11 DPI. Tissues of small intestines displayed significant macroscopic and microscopic lesions with clear viral antigen expression. However, no significant differences among groups were found in challenged piglets. Then alteration in gut microbiota in the jejunum and colon of PDCoV infected-piglets were analyzed using 16S rRNA sequencing. PDCoV infection reduced bacterial diversity and richness, and significantly altered the structure and abundance of the microbiota from the phylum to genus. Fusobacterium, and Proteobacteria was significantly increased (P < 0.05), while the abundance of Bacteroidota was markedly decreased in the infected-piglets. Furthermore, microbial function prediction indicated that the changes in intestinal bacterial also affected the immune system, excretory system, circulatory system, neurodegenerative disease, cardiovascular disease, xenobiotics biodegradation and metabolism, etc. These findings suggest that regulating gut microbiota community may be an effective approach for preventing PDCoV infection.

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