文献类型： 外文期刊
作者： Zhan, Xiaohui 1 ; Zhang, Fengjuan 2 ; Li, Ning 1 ; Xu, Kai 1 ; Wang, Xiaodi 1 ; Gao, Shenghua 1 ; Yin, Yanxu 1 ; Yuan, Weiling 1 ; Chen, Weifang 1 ; Ren, Zhiyong 1 ; Yao, Minghua 1 ; Wang, Fei 1 ;
作者机构： 1.Hubei Acad Agr Sci, Cash Crops Res Inst, Hubei Key Lab Vegetable Germplasm Innovat & Genet, Wuhan 430062, Peoples R China
2.Hubei Univ, Sch Life Sci, State Key Lab Biocatalysis & Enzyme Engn, Wuhan 430062, Peoples R China
3.Hubei Hongshan Lab, Wuhan 430070, Peoples R China
关键词：
CRISPR/Cas9; CRISPR/Cas13; virus resistance;
期刊名称：PLANTS-BASEL （ 影响因子：4.1； 五年影响因子：4.5 ）
ISSN： 2223-7747
年卷期： 2024 年 13 卷 23 期
页码：
收录情况： SCI
摘要： Clustered regularly interspaced short palindromic repeats (CRISPR)/Cas have been recognized as powerful genome-editing tools in diverse eukaryotic species, including plants, and thus hold great promise for engineering virus resistance in plants. Nevertheless, further attention is required regarding various issues associated with applying new powerful technologies in the field. This mini-review focuses on the recent advances in using CRISPR/Cas9 and CRISPR/Cas13 systems to combat DNA and RNA viruses in plants. We explored the utility of CRISPR/Cas for targeting the viral genome and editing host susceptibility genes in plants. We also provide insights into the limitations and challenges of using CRISPR/Cas for plant virus interference and propose individual combinatorial solutions. In conclusion, CRISPR/Cas technology has the potential to offer innovative and highly efficient approaches for controlling viruses in important crops in the near future.
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