Copper and Zinc Treatments Alter the Thyroid Endocrine System in Zebrafish Embryos/Larvae
文献类型： 外文期刊
作者： Zhong, Liqiao 1 ; Zhang, He 2 ; Wu, Luyin 1 ; Ru, Huijun 1 ; Wei, Nian 1 ; Yao, Fan 1 ; Ni, Zhaohui 1 ; Duan, Xinbin 1 ; Li, Yunfeng 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Fishery Resources & Environm Sci Expt Stn Upper Mi, Minist Agr & Rural Affairs, Wuhan 430223, Peoples R China
2.Wenzhou Univ, Coll Life & Environm Sci, Zhejiang Prov Key Lab Subtrop Water Environm & Mar, Wenzhou 325035, Peoples R China
3.Hubei Universtiy, State Key Lab Biocatalysis & Enzyme Engn, Wuhan 430062, Peoples R China
关键词： copper and zinc; hypothalamus-pituitary-thyroid axis; thyroid disruption; zebrafish
期刊名称：TOXICS （ 影响因子：4.472； 五年影响因子：5.144 ）
ISSN：
年卷期： 2022 年 10 卷 12 期
页码：
收录情况： SCI
摘要： Copper (Cu2+) and zinc (Zn2+) are two kinds of heavy metals essential to living organisms. Cu2+ and Zn2+ at excessive concentrations can cause adverse effects on animals, but little is known about the thyroid-disrupting effects of these metals in fish, especially in the early developmental transition stage from embryos to larvae. Wild-type zebrafish embryos were used to expose to Cu2+ (0, 1.5, 15, and 150 mu g/L) and Zn2+ (0, 20, 200, and 2000 mu g/L) for 120 h. Thyroid hormone contents and transcriptional changes of the genes connected with the hypothalamic-pituitary-thyroid (HPT) axis were measured. Results showed that zebrafish embryos/larvae malformation rates were significantly increased in the Cu2+ and Zn2+ groups. Remarkably elevated thyroxine (T4) concentrations and reduced triiodothyronine (T3) concentrations were observed in Cu2+ and Zn2+ exposure fish. And the expression patterns of genes connected with the HPT axis were changed after Cu2+ and Zn2+ treatment. Based on principal component analysis (PCA) results, Zn2+ caused significant effects on the thyroid endocrine system at 200 mu g/L, while Cu2+ resulted in thyroid disruption as low as 1.5 mu g/L. In short, our study demonstrated that exposure to Cu2+ and Zn2+ induced developmental toxicity and thyroid disruption to zebrafish embryos/larvae.
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