文献类型： 外文期刊
作者： Yang, Mo 1 ; Li, Zehou 1 ; Chen, Jing 2 ; Li, Yang 2 ; Xu, Ran 3 ; Wang, Meihua 2 ; Xu, Ying 1 ; Chen, Rong 4 ; Ji, Weiwei 1 ; Li, Xiaoxia 1 ; Wei, Jiayu 1 ; Zhou, Zhengrong 1 ; Ren, Minjie 1 ; Ma, Ke 1 ; Guan, Jiayu 1 ; Mo, Guoxiang 1 ; Zhou, Peng 5 ; Shu, Bo 2 ; Guo, Jingjing 3 ; Yuan, Yuan 6 ; Shi, Zheng-Li 2 ; Zhang, Shuijun 1 ;
作者机构： 1.Nanjing Agr Univ, Coll Life Sci, Nanjing, Peoples R China
2.Chinese Acad Sci, Wuhan Inst Virol, Key Lab Virol & Biosafety, Wuhan, Peoples R China
3.Macao Polytech Univ, Fac Appl Sci, Ctr Artificial Intelligence Driven Drug Discovery, Taipa, Macao, Peoples R China
4.Jiangsu Acad Agr Sci, Inst Vet Med, Key Lab Vet Biol Engn & Technol, Minist Agr, Nanjing, Peoples R China
5.Guangzhou Int Bio Isl, Guangzhou Lab, Guangzhou, Guangdong, Peoples R China
6.Anhui Univ, Sch Life Sci, Hefei, Anhui, Peoples R China
期刊名称：PLOS PATHOGENS （ 影响因子：4.9； 五年影响因子：5.4 ）
ISSN： 1553-7366
年卷期： 2024 年 20 卷 11 期
页码：
收录情况： SCI
摘要： Middle East respiratory syndrome coronavirus (MERS-CoV) and the pangolin MERS-like coronavirus MjHKU4r-CoV-1 employ dipeptidyl peptidase 4 (DPP4) as an entry receptor. MjHKU4r-CoV-1 could infect transgenic mice expressing human DPP4. To understand the mechanism of MjHKU4r-CoV-1 entry into cells, we determined the crystal structures of the receptor binding domain (RBD) of MjHKU4r-CoV-1 spike protein bound to human DPP4 (hDPP4) and Malayan pangolin DPP4 (MjDPP4), respectively. The overall hDPP4-binding mode of MjHKU4r-CoV-1 RBD is similar to that of MERS-CoV RBD. MjHKU4r-CoV-1 RBD shows higher binding affinity to hDPP4 compared to the bat MERS-like coronavirus Ty-BatCoV-HKU4. Via swapping residues between MjHKU4r-CoV-1 RBD and Ty-BatCoV-HKU4 RBD, we identified critical determinants on MjHKU4r-CoV-1 that are responsible for virus usage of hDPP4. Our study suggests that MjHKU4r-CoV-1 is more adapted to the human receptor compared to the bat HKU4 coronavirus and highlights the potential of virus emergence into the human population.
- 相关文献
作者其他论文 更多>>
-
Identification of a functional vitamin D response element in the promoter of goose anti-Müllerian hormone gene
作者：Chen, Rong;Chen, Chen;Qin, Yifei;Liu, Jie;Lei, Mingming;Zhu, Huanxi;Shi, Zhendan;Chen, Rong;Chen, Chen;Qin, Yifei;Liu, Jie;Lei, Mingming;Zhu, Huanxi;Shi, Zhendan
关键词：Goose; Anti-M & uuml;llerian hormone; Vitamin D response element
-
Enteromorpha-derived Fe/N-rich carbon for efficient degradation of thiacloprid via catalytic ozonation
作者：Xuan, Fengxu;Li, Yang;Zhang, Shizhen;Li, Xuanke;Wu, Ling;Yang, Lufang;Lv, Fujian;Wang, Mingxi
关键词：Enteromorpha; Fe/N-rich carbon; Catalytic ozonation; Thiacloprid; Reaction mechanism
-
Water production efficiency and economic benefits under diversified planting modes of intercropping-multiple cropping in arid regions
作者：Zhang, Na;Zhang, Na;Chen, Jing;Jin, Jianxin
关键词：
-
Recombinant canine distemper virus expressing virus-like particle VP2 protein of mink enteritis virus protects minks against lethal challenges of both viruses
作者：Jiang, Yuan;Sun, Yiyang;Zhai, Boyu;Chen, Tianjie;Li, Yang;Ren, Lina;Ma, Yuchen;Han, Kun;Zhao, Jianjun;Wang, Jianke;Bi, Zhenwei;Hu, Bo
关键词：Mink; Canine distemper virus; Mink enteritis virus; Capsid protein 2; Virus-like particles; Bivalent live vaccine
-
A Novel Camel Milk-Derived Peptide LLPK Improves Glucose-Lipid Metabolism in db/db Mice via PPAR Signaling Pathway
作者：Han, Binsong;Ye, Yuhui;Zhang, Cunzheng;Han, Binsong;Zhang, Lina;Zhou, Peng;Han, Binsong;Zhang, Lina;Zhou, Peng
关键词：camel milk-derived peptide; diabetes; hepatic proteome; PPAR signaling pathway
-
Reproductive characteristics and methods to improve reproductive performance in goose production: A systematic review
作者：Yan, Leyan;Liu, Jie;Chen, Rong;Lei, Mingming;Guo, Binbin;Chen, Zhe;Dai, Zichun;Zhu, Huanxi
关键词：Goose; Reproduction; Light; Seasonal breeding; Broody behavior
-
OsDNR1 as a key regulator of rice resistance to 4-hydroxyphenylpyruvate dioxygenase-inhibiting herbicides
作者：Li, Yang;Zhang, Baolong;Li, Yang;Ling, Xitie;Zhang, Wenting;Guo, Dongshu;Wang, Jinyan;Qiu, Zeyu;Lv, Yuanda;Yang, Yuwen;Liu, Qing;Hou, Xiaodong;Zhang, Baolong;Li, Yang;Ling, Xitie;Zhang, Wenting;Guo, Dongshu;Wang, Jinyan;Qiu, Zeyu;Lv, Yuanda;Yang, Yuwen;Liu, Qing;Hou, Xiaodong;Zhang, Baolong;Ling, Xitie;Zhang, Wenting;Guo, Dongshu;Wang, Jinyan;Qiu, Zeyu;Lv, Yuanda;Yang, Yuwen;Liu, Qing;Hou, Xiaodong;Zhang, Baolong
关键词：
