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Microbiome-Metabolomics Analysis Reveals the Mechanism of Holothuria leucospilota Polysaccharides (HLP) in Ulcerative Colitis

文献类型： 外文期刊

作者： Zhang, Xin 1 ; Zhu, Kexue 2 ; Zeng, Shunjiang 1 ; Zheng, Yuanping 1 ; Cao, Jun 1 ; Li, Chuan 1 ;

作者机构： 1.Hainan Univ, Engn Res Ctr Utilizat Trop Polysaccharide Resource, Sch Food Sci & Engn, Minist Educ, Haikou 570228, Peoples R China

2.Chinese Acad Trop Agr Sci, Spice & Beverage Res Inst, Wanning 571533, Peoples R China

3.Dalian Polytech Univ, Collaborat Innovat Ctr Prov & Ministerial Coconstr, Dalian 116034, Peoples R China

关键词： Holothuria leucospilota; intestinal microorganism; mechanism; metabonomic; polysaccharides; ulcerative colitis

期刊名称：MOLECULAR NUTRITION & FOOD RESEARCH （ 影响因子：5.2； 五年影响因子：6.2 ）

ISSN： 1613-4125

年卷期： 2023 年 67 卷 10 期

页码：

收录情况： SCI

摘要： ScopeHolothuria leucospilota polysaccharides (HLP) are bioactive polysaccharides with immunomodulatory effects. This study aims to investigate the impact of HLP on dextran sodium sulfate (DSS)-induced colitis in rats and further investigate the complex interactions between changes in intestinal microbiota, cometabolites, and intestinal inflammation under HLP intervention. Methods and resultsThe ulcerative colitis (UC) model of Sprague Dawley (SD) rats is established by a normal diet with 3%DSS. The effects of HLP on UC are studied by gavage of different doses of HLP for 2 weeks. The results show that HLP alleviate the inflammation of UC and reduce histological damage and secretion of tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-1 beta, and IL-10. After HLP treatment, the intestinal flora of UC rats is regulated, and the flora diversity is restored. Fecal metabolomics analysis reveal the modulatory effects of HLP on amino acid metabolism, antimicrobial peptide anabolism, and energy metabolism in rats with colitis. Correlation analysis of microbial and intestinal metabolites reveals the potential mechanism of HLP affecting colitis. ConclusionHLP repair the intestinal compartment's metabolic disorder by regulating intestinal flora's structure and alleviating colonic mucosal injury and inflammation in colitis rats.

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