Immune and physiological responses of Mytilus unguiculatus to Alexandrium spp. with varying paralytic shellfish toxin profiles
文献类型： 外文期刊
作者： Wu, Haiyan 1 ; Yang, Yuecong 3 ; Zhang, Qianru 1 ; Zheng, Guanchao 1 ; Geng, Qianqian 1 ; Tan, Zhijun 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Minist Agr, Yellow Sea Fisheries Res Inst, Key Lab Testing & Evaluat Aquat Prod Safety & Qual, Qingdao 266071, Peoples R China
2.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, State Key Lab Mariculture Biobreeding & Sustainabl, Qingdao 266071, Peoples R China
3.Shanghai Ocean Univ, Coll Food Sci & Technol, Shanghai 201306, Peoples R China
关键词： Total PSTs content; Total hemocyte count; Immunity; Nucleotide imbalance; Bivalve
期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：8.2； 五年影响因子：8.6 ）
ISSN： 0048-9697
年卷期： 2024 年 935 卷
页码：
收录情况： SCI
摘要： The innate immunity of bivalves serves as the initial defense mechanism against environmental pollutants, ultimately impacting genetic regulatory networks through synergistic interactions. Previous research has demonstrated variations in the accumulation and tolerance capacities of bivalves; however, the specific mechanism underlying the low accumulation of PSTs in M. unguiculatus remains unclear. This study examined the alterations in feeding behavior and transcriptional regulation of M. unguiculatus following exposure to two Alexandrium strains with distinct toxin profiles, specifically gonyautoxin (AM) and N-sulfocarbamoyl toxin (AC). The total accumulation rate of PSTs in M. unguiculatus was 43.64 % (AC) and 27.80 % (AM), with highest PSTs content in the AM group (455.39 mu g STXeq/kg). There were significant variations (P < 0.05) in physiological parameters, such as total hemocyte count, antioxidant superoxide activity and tissue damage in both groups. The absorption rate was identified as the key factor influencing toxin accumulation. Transcriptomic analyses demonstrated that PSTs triggered upregulation of endocytosis, lysosome, and immune-related signaling pathways. Furthermore, PSTs induced a nucleotide imbalance in the AC group, with total PSTs content serving as the most toxic indicator. These results suggested that protein-like substances had a crucial role in the stress response of M. unguiculatus to PSTs. This study provided novel perspectives on the impacts of intricate regulatory mechanisms and varying immune responses to PSTs in bivalves.
- 相关文献
作者其他论文 更多>>
-
A novel ZIF-L/PEI thin film nanocomposite membrane for removing perfluoroalkyl substances (PFASs) from water: Enhanced retention and high flux
作者：Bi, Yujie;Meng, Xiangmin;Yong, Qiaozhi;Wang, Xinping;Tan, Zhijun;Geng, Qianqian;Peng, Jixing;Sun, Xiaojie;Guo, Mengmeng
关键词：Perfluoroalkyl substances (PFASs); Thin film nanocomposite (TFN); Metal-organic framework (MOF); Density functional theory (DFT); Nanofiltration (NF)
-
Integrated evidence of transcriptional, metabolic, and intestinal microbiota changes in Ruditapes philippinarum due to perfluorooctanoic acid-induced immunotoxicity
作者：Li, Fengling;Gong, Xiuqiong;Zhou, Yang;Geng, Qianqian;Jiang, Yanhua;Yao, Lin;Qu, Meng;Tan, Zhijun;Gong, Xiuqiong;Zhou, Yang;Tan, Zhijun
关键词：Perfluorooctanoic acid; Immunotoxicity; Intestine microbiota; Metabolome; Transcriptome; Bivalve
-
Contamination Status and Risk Assessment of Paralytic Shellfish Toxins in Shellfish along the Coastal Areas of China
作者：Zheng, Guanchao;Xu, Xizhen;Wu, Haiyan;Fan, Liqiang;Peng, Jixing;Guo, Mengmeng;Tan, Zhijun;Xu, Xizhen;Wang, Qianrui;Yang, Dajin;Tan, Zhijun
关键词：paralytic shellfish toxins; shellfish; liquid chromatography-tandem mass spectrometry (LC-MS/MS); risk assessment; China
-
Influence of humic acid on the bioaccumulation, elimination, and toxicity of PFOS and TBBPA co-exposure in Mytilus unguiculatus Valenciennes
作者：Geng, Qianqian;Zou, Liang;Guo, Mengmeng;Li, Fengling;Qin, Hanlin;Tan, Zhijun;Geng, Qianqian;Liu, Xiangxiang;Wang, Xu;Zou, Liang;Liu, Hong;Wang, Xu;Tan, Zhijun
关键词：Perfluoroalkyl acids; Brominated flame retardant; Dissolved organic matter; Bioconcentration; Mussel; Co-exposure
-
Integrative Inducer Intervention and Transcriptomic Analyses Reveal the Metabolism of Paralytic Shellfish Toxins in Azumapecten farreri
作者：Dong, Chenfan;Zheng, Guanchao;Peng, Jixing;Guo, Mengmeng;Wu, Haiyan;Dong, Chenfan;Tan, Zhijun;Tan, Zhijun
关键词：cytochrome P450; glutathione S-transferase; ATP-binding cassette transporter; rifampin; dl-alpha-tocopherol; colchicine
-
Explainable machine learning for predicting the geographical origin of Chinese Oysters via mineral elements analysis
作者：Kang, Xuming;Zhao, Yanfang;Yao, Lin;Tan, Zhijun;Tan, Zhijun;Tan, Zhijun
关键词：Oyster; Elemental profile; Explainable machine learning; SHAP; Geographical origin
-
Risk characteristics of shellfish toxins in Mytilus unguiculatus around the Zhoushan Islands, East China Sea
作者：Che, Hanyu;Zheng, Guanchao;Che, Hanyu;Wu, Haiyan;Deng, Yuxiang;Guo, Mengmeng;Peng, Jixing;Tan, Zhijun;Cheng, Ling;Liu, Lijuan;Tan, Zhijun
关键词：Shellfish toxins; Mytilus unguiculatus; LC-MS/MS; Zhoushan; Temporal distribution
