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Effects of different concentrations and particle sizes of nanoplastics on gut microbiology, metabolism, and immunity in Chiromantes dehaani

文献类型： 外文期刊

作者： Han, Mingming 3 ; Zhu, Tian 3 ; Zhou, Zihan 1 ; Si, Qin 4 ; Zhu, Chenxi 5 ; Li, Yiming 2 ; Jiang, Qichen 1 ;

作者机构： 1.Freshwater Fisheries Res Inst Jiangsu Prov, 79 Chating East St, Nanjing 210017, Peoples R China

2.Chinese Acad Fisheries Sci, Fishery Machinery & Instrument Res Inst, Shanghai 200092, Peoples R China

3.Univ Sains Malaysia, Ctr Marine & Coastal Studies, Minden 11800, Penang, Malaysia

4.Jiangsu Maritime Inst, 309 Gezhi Rd, Nanjing 211170, Jiangsu, Peoples R China

5.Univ Sains Malaysia, Sch Humanities, Geog, Minden 11800, Penang, Malaysia

关键词： Chiromantes dehaani; Gut microorganisms; Intestinal biochemical composition; Metabolism; Immunity

期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：4.7； 五年影响因子：4.7 ）

ISSN： 1050-4648

年卷期： 2024 年 147 卷

页码：

收录情况： SCI

摘要： This study investigated the effects of nanoplastics (NPs) of varying particle sizes (75, 500, and 1000 nm) and concentrations (2.5 and 10 mg/L) on the gut health of Chiromantes dehaani. The experimental groups included a control (Cg0), and varying combinations of particle size and concentration. Our results showed that 75 nm NPs were more likely to enhance pathogenic bacterial growth than other sized NPs. Compared with CK, Low NPs concentrations (2.5 mg/L) raised total cholesterol (T-CHO) levels in the gut, while high concentrations significantly decreased both triglyceride (TG) and T-CHO levels (p < 0.05). The enzymatic activities of intestinal lipase and amylase were inhibited by NPs exposure, with greater inhibition at higher NPs concentrations. The 500 nm NPs exhibited a notably higher inhibitory effect than the 75 and 1000 nm NPs (P < 0.05). In terms of apoptosis, NPs exposure led to reduced mRNA expression of Bcl2 and increased expression of Caspase-3, Caspase-8, and Caspase-9, indicating an induction of apoptosis. This effect was more pronounced at higher NPs concentrations, with 75 nm NPs more likely to induce apoptosis in intestinal cells than 500 nm and 1000 nm NPs. Moreover, NPs triggered intestinal inflammatory responses, evidenced by the increased mRNA expression of TNF-beta, TNF-alpha, IL1 beta, IL6, and IL8, and the decreased expression of IL10. High NPs concentrations were more likely to induce intestinal inflammation, with 500 nm NPs imparting the strongest effect. In summary, the study demonstrated that NPs, and particularly those at higher concentrations, disrupted the gut environment of C. dehaani by altering the microflora, reducing microbial diversity, inhibiting digestion and metabolism, inducing apoptosis, and triggering inflammation. Among the sizes of NPs tested, 500 nm NPs had the most significant adverse impact on digestion, metabolism, and inflammation, while 75 nm NPs most strongly induced apoptosis in C. dehaani's intestinal cells.

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