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Green tea polyphenols inhibit growth, pathogenicity and metabolomics profiles of Streptococcus suis

文献类型： 外文期刊

作者： Gao, Ting 1 ; Ye, Fei 2 ; Yuan, Fangyan 1 ; Liu, Zewen 1 ; Liu, Wei 1 ; Zhou, Danna 1 ; Yang, Keli 1 ; Guo, Rui 1 ; Wang, Ningning 1 ; Zhang, Tengfei 1 ; Zhou, Rui 3 ; Tian, Yongxiang 1 ;

作者机构： 1.Hubei Acad Agr Sci, Inst Anim Husb & Vet,Minist Agr & Rural Affairs, Key Lab Prevent & Control Agents Anim Bacteriosis, Hubei Prov Key Lab Anim Pathogen Microbiol, Wuhan, Peoples R China

2.Hubei Acad Agr Sci, Inst Fruit & Tea, Wuhan, Peoples R China

3.Huazhong Agr Univ, Coll Vet Med, State Key Lab Agr Microbiol, Wuhan, Peoples R China

4.Cooperat Innovat Ctr Sustainable Pig Prod, Wuhan, Peoples R China

关键词： Streptococcus suis; Green tea polyphenols; Growth; Pathogenicity; Untargeted metabolomics

期刊名称：MICROBIAL PATHOGENESIS （ 影响因子：3.848； 五年影响因子：3.957 ）

ISSN： 0882-4010

年卷期： 2022 年 164 卷

页码：

收录情况： SCI

摘要： Streptococcus suis (SS) is an important pathogen in pigs and can also cause severe infection in humans. Currently, more and more drug resistance is reported, resulting in the search for new drugs being needed urgently. Green tea polyphenols (GTP) was reported to inhibit many bacteria. However, SS response to GTP has not been studied before. In this report, the effect of GTP on growth, cell integrity, pathogenicity and metabolic pathway of SS was examined. The GTP inhibited growth, led to cellular damage, and attenuated pathogenicity of SS. Finally, GTP affected many important metabolic pathways of SS, such as ABC transporters, pyrimidine metabolism, protein digestion and absorption. The results provide new insight into the prevention and control of SS infection.

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