Taurine reduction of injury from neutrophil infiltration ameliorates Streptococcus uberis-induced mastitis
文献类型： 外文期刊
作者： Li, Ming 1 ; Wang, Zhenglei 1 ; Fu, Shaodong 1 ; Sun, Naiyan 1 ; Li, Weizhen 2 ; Xu, Yuanyuan 1 ; Han, Xiangan 3 ; Zhang, Jinqiu 4 ; Miao, Jinfeng 1 ;
作者机构： 1.Nanjing Agr Univ, Coll Vet Med, MOE Joint Int Res Lab Anim Hlth & Food Safety, Key Lab Anim Physiol & Biochem, Nanjing 210095, Peoples R China
2.Yunnan Agr Univ, Coll Vet Med, Kunming 650201, Peoples R China
3.Chinese Acad Agr Sci, Shanghai Vet Res Inst, Shanghai 200241, Peoples R China
4.Jiangsu Acad Agr Sci, Natl Res Ctr Vet Vaccine Engn & Technol China, Nanjing 210014, Peoples R China
关键词： Taurine; Streptococcus uberis; Mastitis; Blood-milk barrier; TAK1/MAPK/NF-kappa B; AMPK/Nrf2
期刊名称：INTERNATIONAL IMMUNOPHARMACOLOGY （ 影响因子：5.6； 五年影响因子：5.6 ）
ISSN： 1567-5769
年卷期： 2023 年 124 卷
页码：
收录情况： SCI
摘要： Mastitis is a common disease of dairy cows characterized by infiltration of leukocytes, especially neutrophils, resulting in increased permeability of the blood-milk barrier (BMB). Taurine, a functional nutrient, has been shown to have anti-inflammatory and antioxidant effects. Here, we investigated the regulatory effects and mechanisms of taurine on the complex immune network of the mammary gland in Streptococcus uberis (S. uberis) infection. We found that taurine had no direct effect on CXCL2-mediated neutrophil chemotaxis. However, it inhibited MAPK and NF-kappa B signalings by modulating the activity of TAK1 downstream of TLR2, thereby reducing CXCL2 expression in macrophages to reduce neutrophil recruitment in S. uberis infection. Further, the AMPK/ Nrf2 signaling pathway was activated by taurine to help mitigate oxidative damage, apoptosis and disruption of tight junctions in mammary epithelial cells caused by hypochlorous acid, a strong oxidant produced by neutrophils, thus protecting the integrity of the mammary epithelial barrier. Taurine protects the BMB from damage caused by neutrophils via blocking the macrophage-CXCL2-neutrophil signaling axis and increasing the antioxidant capacity of mammary epithelial cells.
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