Staphylococcus aureus Conquers Host by Hijacking Mitochondria via PFKFB3 in Epithelial Cells
文献类型： 外文期刊
作者： Gao, Xing 1 ; Feng, Shiyuan 2 ; Wu, Binfeng 1 ; Liu, Laizhen 1 ; Xu, Yuanyuan 1 ; Zhang, Jinqiu 3 ; Miao, Jinfeng 1 ;
作者机构： 1.Nanjing Agr Univ, Coll Vet Med, Minist Educ, Joint Int Res Lab Anim Hlth & Food Safety, Nanjing 210014, Peoples R China
2.Nanjing Agr Univ, Sanya Res Inst, Sanya, Peoples R China
3.Jiangsu Acad Agr Sci, Inst Vet Immunol & Engn, Nanjing, Peoples R China
4.Minist Sci & Technol, Jiangsu Key Lab Food Qual & Safety, State Key Lab Cultivat Base, Nanjing, Peoples R China
关键词： glycolysis; SIRT3-HIF1 alpha; mitophagy; PFKFB3; Staphylococcus aureus
期刊名称：JOURNAL OF INFECTIOUS DISEASES （ 影响因子：6.4； 五年影响因子：5.4 ）
ISSN： 0022-1899
年卷期： 2024 年
页码：
收录情况： SCI
摘要： Staphylococcus aureus persists within mammary epithelial cells for an extended duration, exploiting the host metabolic resources to facilitate replication. This study revealed a mechanism by which intracellular S aureus reprograms host metabolism, with PFKFB3 playing a crucial role in this process. Mechanistically, S aureus induced mitochondrial damage, leading to increased levels of mitochondrial reactive oxygen species and dysfunction in the electron transport chain. Moreover, S aureus shifted the balance of mitochondrial dynamics from fusion to fission, subsequently activating PINK1-PRKN-dependent mitophagy, causing loss of sirtuin 3 to stabilize hypoxic inducible factor 1 alpha, and shifting the host metabolism toward enhanced glycolysis. The inhibition of PFKFB3 reversed the mitochondrial damage and degradation of sirtuin 3 induced by S aureus. Overall, our findings elucidate the mechanism by which S aureus reprograms host metabolism, thereby offering insights into the treatment of S aureus infection. Staphylococcus aureus induced sirtuin 3 degradation via mitophagy, thereby shifting metabolism toward glycolysis. Inhibition of PFKFB3 reduced mitochondrial damage by limiting reactive oxygen species production and alleviated the degradation of sirtuin 3.
- 相关文献
作者其他论文 更多>>
-
Immunogenicity of a novel HMT13 adjuvant-based inactivated vaccine against Avian pathogenic Escherichia coli serogroups O36, O78, and O109
作者：Jia, Chaoying;Wang, Zesong;Liu, Qingyun;Wang, Xiangru;Jia, Chaoying;Wang, Zesong;Liu, Qingyun;Wang, Xiangru;Fu, Jiyang;Li, Zugang;Yu, Jiangxu;Liu, Qingyun;Wang, Xiangru;Zhang, Jinqiu
关键词：Avian colibacillosis; APEC; Inactivated vaccine; HMT 13; Adjuvant
-
STING contributes to the inflammation and proliferation of Staphylococcus aureus via mitochondrial reactive oxygen species-hypoxic inducible factor 1α axis in epithelial cells
作者：Gao, Xing;Wu, Binfeng;Qiu, Yawei;Miao, Jinfeng;Feng, Shiyuan;Zhang, Jinqiu;Zhang, Jinqiu
关键词：STING; mastitis; mROS-HIF1 alpha; glycolysis;
Staphylococcus aureus -
Alginate di-aldehyde-modified metal-organic framework nanocarriers as delivery platform and adjuvant in inactivated pseudorabies vaccination
作者：Yin, Wenzhu;Chang, Chen;Zhao, Yanhong;Wang, Haiyan;Zhang, Jinqiu;Ma, Fang;Zuo, Xiaoxin;Tang, Bo;Lu, Yu;Yin, Wenzhu;Xu, Zeyu;Tang, Bo;Yin, Wenzhu;Lu, Yu
关键词：
-
A critical role for host-derived cystathionine-β-synthase in Staphylococcus aureus-induced udder infection
作者：Fu, Shaodong;Yang, Bo;Gao, Yabin;Qiu, Yawei;Sun, Naiyan;Li, Zhi;Feng, Shiyuan;Xu, Yuanyuan;Miao, Jinfeng;Zhang, Jinqiu;Luo, Zhenhua;Han, Xiangan
关键词：Staphylococcus aureus; Cystathionine; beta-synthase; Udder infection; Blood -milk barrier
-
QSAR Studies on a Class of Benzofuranene Cyanide Derivatives as Potential Inhibitors Targeting Staphylococcus aureus Sortase A
作者：Yang, Bo;Fu, Shaodong;Qiu, Yawei;Miao, Jinfeng;Zhang, Jinqiu;Zhang, Jinqiu
关键词：Staphylococcus aureus; sortase a; inhibitors; quantitative structure-activity relationship; molecular descriptors; drug design
-
Analysis of Rfo-Mediated Network in Regulating Fertility Restoration in Brassica oleracea
作者：Xing, Miaomiao;Xu, Yuanyuan;Lu, Yuyu;Yan, Jiyong;Zeng, Aisong
关键词：
Rfo ; Ogura CMS; transcriptomics; fertility restoration; tapetum;Brassica oleracea -
Formulation and Evaluation of Lipidized Imiquimod as an Effective Adjuvant
作者：Yin, Wenzhu;Deng, Bihua;Wang, Haiyan;Ma, Fang;Zhou, Mingxu;Lu, Yu;Zhang, Jinqiu;Xu, Zeyu;Lu, Yu;Zhang, Jinqiu
关键词：adjuvant; imiquimod; cholesterol; liposolubility; foot-and-mouth disease
